Akademska digitalna zbirka SLovenije - logo
VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
  • Procoagulant properties of bare and highly PEGylated vinyl-modified silica nanoparticles
    Tavano, Regina ...
    Undesired alterations of the blood clotting balance may follow the intravascular injection of nanotherapeutics/diagnostics. Here, we tested the procoagulant activity of synthetic amorphous silica ... (SAS) and organically modified silica (ORMOSIL) nanoparticles (NPs) and whether a high-density polyethylene glycol coating minimizes these effects. Materials & methods: Hageman factor- and tissue factor-dependent activation of human blood/plasma coagulation, and binding to human monocytes, endothelial cells and platelets were quantified in vitro using naked and PEGylated ORMOSIL-NPs. Their effects were compared with those of SAS-NPs, present in many industrial products, and of poly(lactic-co-glycolic acid)- and small unilamellar vesicles-NPs, already approved for use in humans. Results: Both SAS-NPs and ORMOSIL-NPS presented a significant procoagulant activity. However, highly PEGylated ORMOSIL-NPs were particularly averse to the interaction with the soluble factors and cellular elements that may lead to intravascular blood coagulation. Conclusion: Stealth, highly PEGylated ORMOSIL-NPs with a poor procoagulant activity can beused as starting blocks to design hemocompatible nanomedical-devices.
    Vir: Nanomedicine. - ISSN 1743-5889 (vol. 5, no. 6, 2010, str. 881-896)
    Vrsta gradiva - članek, sestavni del
    Leto - 2010
    Jezik - angleški
    COBISS.SI-ID - 2846833

    Povezava(-e):

    http://www.futuremedicine.com/doi/abs/10.2217/nnm.10.65

vir: Nanomedicine. - ISSN 1743-5889 (vol. 5, no. 6, 2010, str. 881-896)
loading ...
loading ...
loading ...

Vnos na polico