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  • Self-rated health predicts adverse events during beta-blocker treatment : the CIBIS-ELD randomised trial analysis
    Lainščak, Mitja ...
    BACKGROUND: Self-rated health (SRH) predicts outcome in patients with heart failure. Beta-blockers are known to improve health-related quality of life andreduce mortality in such patients. We aimed ... to evaluate the relation between SRH and adverse events during titration of beta-blockers in elderly patients with heart failure. METHODS: The cardiac insufficiency bisoprolol study in the elderly (CIBIS-ELD) is a multicentre, double-blind trial, in which 883 patients aged >/=65years with chronic heart failure (73+/-6years, 38% women, left ventricular ejection fraction šLVEFđ 42%+/-14%) were randomised to bisoprolol or carvedilol. SRH was assessed at baseline and after 12weeks, using a 5-grade descriptive scale: excellent, very good, good, fair, and poor. RESULTS: Median SRH at baseline and follow-up was good, but more patients reported fair/poor SRH at baseline (36% vs. 30%, p=0.012). Women, beta-blocker-naive patients, patients in NYHA class III/IV and those with PHQ-9 score >/=12 were more likely to report fair/poor baseline SRH (p<0.001 for all). During follow-up, SRH improved in 34% of patients and worsened in 8% (p<0.001). Adverse events were experienced by 64% patients and38% experienced >1 adverse event or serious adverse event, with higher prevalence in lower SRH categories. In a multivariate logistic regression model, SRH, age, distance achieved on the 6-min walk test and LVEF >45% predicted adverse events (p<0.05 for all). CONCLUSIONS: SRH is an independent predictor of adverse events during titration of beta-blockers and correlates with the proportion and number of adverse events per patient.
    Vir: International journal of cardiology. - ISSN 0167-5273 (Vol. 163, iss. 1, 2013, Str. 87-92)
    Vrsta gradiva - članek, sestavni del ; neleposlovje za odrasle
    Leto - 2013
    Jezik - angleški
    COBISS.SI-ID - 28561113
    DOI

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