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STING-dependent interferon-[lambda]1 induction in HT29 cells, a human colorectal cancer cell line, after gamma-radiationChen, Jianzhou ...Purpose To investigate the induction of type III interferons (IFNs) in human cancer cells by gamma-rays. Methods and Materials Type III IFN expression in human cancer cell lines after gamma-ray ... irradiation in vitro was assessed by reverse transcription%quantitative polymerase chain reaction and enzyme-linked immunosorbent assay. Signaling pathways mediating type III IFN induction were examined by a variety of means, including immunoblotting, flow cytometry, confocal imaging, and reverse transcription%quantitative polymerase chain reaction. Key mediators in these pathways were further explored and validated using gene CRISPR knockout or short hairpin RNA knockdown. Results Exposure to gamma-rays directly induced type III IFNs (mainly IFNL1) in human cancer cell lines in dose- and time-dependent fashions. The induction of IFNL1 was primarily mediated by the cytosolic DNA sensors%STING%TBK1%IRF1 signaling axis, with a lesser contribution from the nuclear factor kappa b signaling in HT29 cells. In addition, type III IFN signaling through its receptors serves as a positive feedback loop, further enhancing IFN expression via up-regulation of the kinases in the STING%TBK1 signaling axis. Conclusions Our results suggest that IFNL1 can be up-regulated in human cancer cell lines after gamma-ray treatment. In HT29 cells this induction occurs via the STING pathway, adding another layer of complexity to the understanding of radiation-induced antitumor immunity, and may provide novel insights into IFN-based cancer treatment.Vir: International journal of radiation oncology, biology, physics. - ISSN 0360-3016 (Vol. 101, no. 1, 2018, str. 97-106)Vrsta gradiva - članek, sestavni delLeto - 2018Jezik - angleškiCOBISS.SI-ID - 2899323
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vir: International journal of radiation oncology, biology, physics. - ISSN 0360-3016 (Vol. 101, no. 1, 2018, str. 97-106)
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Ime baze podatkov | Področje | Leto |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Chen, Jianzhou | ![]() |
Markelc, Boštjan | 32175 |
Käppler, Jakob Raphael | ![]() |
Ogundipe, Vivian M. L. | ![]() |
Cao, Yunhong | ![]() |
McKenna, Gillies W. | ![]() |
Muschel, Ruth J. | ![]() |
Vir: Osebne bibliografije
in: SICRIS
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