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  • Controlling the elongation phase of transcription with P-TEFb
    Peterlin, Matija Boris ; Price, David H.
    The positive transcription elongation factor b (P-TEFb) is a cyclin-dependent kinase that controls the elongation phase of transcription by RNA polymerase II (RNAPII). This process is made possible ... by the reversal of effects of negative elongation factors that include NELF and DSIF. In complex organisms, elongation control is critical for the regulated expression of most genes. In those organisms, the function of P-TEFb is influenced negatively by HEXIM proteins and 7SK snRNA and positively by a variety of recruiting factors. Phylogenetic analyses of the components of the human elongation control machinery indicate that the number of mechanisms utilized to regulate P-TEFb function increased as organisms developed more complex developmental patterns.
    Vir: Molecular cell. - ISSN 1097-2765 (Vol. 23, issue 3, 2006, str. 297-305)
    Vrsta gradiva - članek, sestavni del
    Leto - 2006
    Jezik - angleški
    COBISS.SI-ID - 29181401
    DOI

vir: Molecular cell. - ISSN 1097-2765 (Vol. 23, issue 3, 2006, str. 297-305)
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