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  • Determination of benzodiazepines in urine via benzophenone derivatives using liquid chromatography-tandem mass spectrometry = Določanje benzodiazepinov v urinu preko benzofenonskih derivatov z uporabo tekočinske kromatografije sklopljene s tandemsko masno spektrometrijo
    Roškar, Robert, 1975- ; Sollner Dolenc, Marija
    The aim of this study was to validate a new method for determining benzodiazepines in urine via their benzophenone derivatives, based on liquid chromatography-tandem mass spectrometry (LC-MS/MS). ... Selected benzodiazepines were analysed after acid hydrolysis of urine and extraction by ethyl acetate in the presence of an internal standard. Samples were analysed using electrospray ionization LC-MS/MS in a multiple reaction monitoring mode. The chromatographic run time on a reversed phase C18 analytical column was set for9 min. This method was validated in 21 patients receiving methadone. Benzodiazepines intake was established in two out of three patients. LC-MS/MS results were also compared with the rapid immunoassay and the methods showed good agreement. However, in three cases benzodiazepines were detected by LC-MS/MS, but not by the immunoassay. The sensitivity of the developed LC-MS/MS method is comparable to or even higher than of previously reported methods, which makes it suitable as a confi rmatory method.
    Vir: Arhiv za higijenu rada i toksikologiju = Archives of industrial hygiene and toxicology. - ISSN 0004-1254 (Vol. 61, no. 4, 2010, str. 381-388)
    Vrsta gradiva - članek, sestavni del
    Leto - 2010
    Jezik - angleški
    COBISS.SI-ID - 2923121

    Povezava(-e):

    http://hrcak.srce.hr/index.php?lang=en&show=casopis&id_casopis=7
    DOI

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