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  • A tetrahydrophthalazine derivative Sodium nucleinate exerts a potent suppressive effect upon LPS-stimulated mononuclear cells in vitro and in vivo = [Derivat tetrahidroftalazina "natrij nukleinat" ima snažni učinak na LPS-om stimulirane mononuklearne stanice in vitro I in vivo]
    Jukić, Tomislav ; Abidov, Musa ; Ihan, Alojz
    We described the use of a new chemical substance Sodium nucleinate (SN) as an immunomodulatory substance exhibiting antiinflammatory properties. Sodium nucleinate (SN) registrated in Russian ... Federation as Tameritr, is 2-amino-1,2,3,4-tetrahydrophthalazine-1,4-dione sodium salt dihydrate, derivative of well known chemical substance luminol. To comprehend the mechanisms of SN immunomodulatory activity, we examined the SN modulation of the innate inflammatory cytokine response of human PBMC stimulated with LPS invitro. Furthermore, we studied the immunomodulatory effects of SN in mice challenged with E. coli LPS in vivo to investigate a possible novel approach to therapy of excessive inflammation that interfere with the response to endotoxin and inflammatory mediators. Our results demonstrated that SN is an efficient inhibitor of sepsis development in mice model of LPS-induced sepsis.The changes induced by SN include decreased mice plasma inflammatory cytokine production. Simmilary we demonstrated a decreased TNF-a, IFN-g and IL-6 response in human LPS-stimulated PBMNCs. SN was therefore shown to be a promising inhibitor of multiple inflammatory cytokine secretion.
    Vir: Collegium antropologicum. - ISSN 0350-6134 (Vol. 35, issue 4, 2011, str. 1219-1223)
    Vrsta gradiva - članek, sestavni del
    Leto - 2011
    Jezik - angleški
    COBISS.SI-ID - 29372889

vir: Collegium antropologicum. - ISSN 0350-6134 (Vol. 35, issue 4, 2011, str. 1219-1223)
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