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GSTT1 null genotype is a risk factor for diabetic retinopathy in Caucasians with type 2 diabetes, whereas GSTM1 null genotype might confer protection against retinopathyCilenšek, Ines ...Aim: Substantial data indicate that oxidative stress is involved in the development of diabetic retinopathy (DR). The aim of the present study was to investigate whether the genetic polymorphisms: ... polymorphic deletions of glutathione S-transferases M1 (GSTM1) and T1 (GSTT1) and Ile105Val of the GSTP1 are associated with DR in Slovenian patients with type 2 diabetes. Methods: In this cross sectional case-control study 604 unrelated Slovene subjects (Caucasians) with type 2 diabetes mellitus were enrolled: 284 patients with DR (cases) and the control group of 320 subjects with type 2 diabetes of more than 10 years' duration who had no clinical signs of DR. Genotypes were determined by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP). Results: In our study, the deletion of the GSTM1 was found less frequent in cases with DR than in the controls (27.5% versus 44.4%; P < 0.001), whereas the deletion of GSTT1 was found significantly more often in cases than in the controls (49.3% versus 29.7%; P < 0.001). We did not find statistically significant differences in the genotype distribution in GSTP1 (Ile105Val) polymorphism between cases and controls (40.5% versus 46.0%). Conclusions: We may conclude that individuals homozygous for the deletion of GSTT1 are at an approximately 2-fold-greater risk of DR, whereas the GSTM1 deficiency is associated with lower frequency ofDR in type 2 diabetics.Vir: Disease markers. - ISSN 0278-0240 (Vol. 32, iss. 2, 2012, str. 93-99)Vrsta gradiva - članek, sestavni delLeto - 2012Jezik - angleškiCOBISS.SI-ID - 29585881
Avtor
Cilenšek, Ines |
Mankoč Ramuš, Sara |
Globočnik Petrovič, Mojca |
Petrovič, Danijel, 1963-
Teme
Diabetic Retinopathy |
Genetics |
Risk Factors |
Genotype |
Diabetes Mellitus, Non-Insulin-Dependent |
Oxidative Stress |
Glutathione Transferases |
Polymorphism (Genetics) |
Ophthalmoscopy |
Polymerase Chain Reaction |
Cross-Sectional Studies |
Genotip |
Sladkorna bolezen, ne-inzulin-odvisna |
Diabetična retinopatija |
Dejavniki tveganja |
Oksidativni stres |
Polimerazna, verižna reakcija |
Oftalmoskopija |
Polimorfizem (genetika) |
Presečne študije
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Cilenšek, Ines | 28348 |
Mankoč Ramuš, Sara | 23487 |
Globočnik Petrovič, Mojca | 20707 |
Petrovič, Danijel, 1963- | 11252 |
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