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International cohort study of 73 anti-Ku-positive patients [Elektronski vir] : association of p70/p80 anti-Ku antibodies with joint/bone features and differentiation of disease populations by using principal-components analysisLakota, Katja ...Introduction: An international cohort study of 73 anti-Ku-positive patients with different connective tissue diseases was conducted to differentiate the anti-Ku-positive populations of patients based ... on their autoantibody profile and clinical signs/symptoms and to establish possible correlations between antibodies against Ku p70 and Ku p80 with autoimmune diseases. Methods: Sera of anti-Ku-positive patients were collected from six European centers and wereall secondarily tested (in the reference center); 73 were confirmed as positive. Anti-Ku antibodies were detected with counter-immunoelectrophoresis (CIE), line immunoassay (LIA), and immunoblot analyses. All clinical and laboratory data were follow-up cumulative data, except for anti-Ku antibodies.Statistical analyses were performed by using R (V 2.12.1). The Fisher Exact test was used to evaluate the association between anti-Ku antibodies and diagnosis, gender, clinical signs, and other observed antibodies. The P values were adjusted for multiple testing. Separation of disease populations based on the presence of antibodies and clinical signs wasinvestigated by principal-components analysis, which was performed by usingthr// R's prcomp function with standard parameters. Results: A 16% higherprevalence of anti-Ku p70 was found over anti-Ku p80 antibodies. In 41 (57%) patients, a combination of both was detected. Five (7%) patients, who were CIE and/or LIA anti-Ku positive, were negative for both subsets, as detected with the immunoblot; 31% of the patients had undifferentiated connective tissue disease (UCTD); 29% had systemic sclerosis (SSc); 18% had systemic lupus erythematosus (SLE); 11% had rheumatoid arthritis; 7% had polymyositis; and 3% had Sjogren syndrome. (Abs. trunc. at 2000 ch.)Vir: Arthritis research & therapy [Elektronski vir]. - ISSN 1478-6362 (Vol. 14, iss. 1, 2012)Vrsta gradiva - e-članek ; neleposlovje za odrasleLeto - 2012Jezik - angleškiCOBISS.SI-ID - 29876185
Avtor
Lakota, Katja |
Thallinger, Gerhard G. |
Sodin-Šemrl, Snežna, 1962- |
Rozman, Blaž, 1944- |
Ambrožič, Aleš, 1966- |
Tomšič, Matija, 1959- |
Praprotnik, Sonja |
Čučnik, Saša |
Mrak Poljšak, Katjuša |
Ceribelli, Angela |
Cavazzana, Ilaria |
Franceschini, Franco |
Vencovský, Jiří |
Czirjak, Laszlo |
Varjú, Cecilia |
Steiner, Gunther |
Aringer, Martin |
Stamenković, Bojana |
Distler, Oliver |
Matucci-Cerinic, Marco |
Kveder, Tanja
Teme
Connective Tissue Diseases |
Autoantibodies |
Autoimmune Diseases |
Counterimmunoelectrophoresis |
Immunoblotting |
Immunoassay |
Follow-Up Studies |
Cohort Studies |
Multicenter Studies |
Europe |
Vezivno tkivo, bolezni |
Protitočna imunoelekroforeza |
Avtoprotitelesa |
Imunoblot |
Avtoimunske bolezni |
Evropa |
Policentrične študije |
Sledilne študije |
Kohortne študije |
Imunski testi
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Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Lakota, Katja | 28845 |
Thallinger, Gerhard G. | ![]() |
Sodin-Šemrl, Snežna, 1962- | 26481 |
Rozman, Blaž, 1944- | 07180 |
Ambrožič, Aleš, 1966- | 19209 |
Tomšič, Matija, 1959- | 13601 |
Praprotnik, Sonja | 13602 |
Čučnik, Saša | 16362 |
Mrak Poljšak, Katjuša | 34804 |
Ceribelli, Angela | ![]() |
Cavazzana, Ilaria | ![]() |
Franceschini, Franco | ![]() |
Vencovský, Jiří | ![]() |
Czirjak, Laszlo | ![]() |
Varjú, Cecilia | ![]() |
Steiner, Gunther | ![]() |
Aringer, Martin | ![]() |
Stamenković, Bojana | ![]() |
Distler, Oliver | ![]() |
Matucci-Cerinic, Marco | ![]() |
Kveder, Tanja | 02066 |
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