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Total plasma sulfide in congestive heart failureKovačić, Dragan ...Background: Hydrogen sulfide (H(2)S) has emerged as a third gaseous transmitter in mammals. In animal models of heart failure, treatment with an H(2)S donor can protect the heart against adverse ... remodeling and attenuate cardiac dysfunction. The aim was to determine total plasma sulfide in patientswith congestive heart failure. Methods and results: Total plasma sulfide was determined in 57 patients on admission to an outpatient clinic orcardiology department. Total plasma sulfide concentrations in these patientswas lower compared with a control group (5.32 š2.22, 8.00đ muM vs. 8.5 š6.00, 14.00đ muM; P = .05). Total plasma sulfide decreased significantlyacross the New York Heart Association (NYHA) functional classes (II, 5.84 š4.33, 8.00đ muM vs. III, 4.67 š4.00, 7.17đ muM vs. IV, 2.67 š2.22, 4.31đ muM; P = .001). The total plasma sulfide negatively correlated with pro-BNP (R(2) cubic, 0.692; P = .001) and pulmonary artery systolic pressure (R(2) cubic, 0.569; P = .001). The receiver operating characteristic analysis of the area under the curve for total plasma sulfide as a predictor of mortality was 0.904 (95% CI, 0.822-0.987; P = .001), and of rehospitalization was 0.779 (95% CI, 0.650-0.908; P = .001). Total plasma sulfide was a univariate predictor of mortality (odds ratio, 0.245; 95% CI, 0.108-0.555; P =.001). Conclusion: Total plasma sulfide is negatively related to severity of congestive heart failure: it is lowest in NYHA Class IV and in patients with high pro-BNP and high pulmonary artery pressure. Low total plasma sulfide predicts a higher mortality rate.Vir: Journal of cardiac failure. - ISSN 1071-9164 (Vol. 18, no. 7, 2012, str. 541-548)Vrsta gradiva - članek, sestavni delLeto - 2012Jezik - angleškiCOBISS.SI-ID - 30114265
Avtor
Kovačić, Dragan |
Glavnik, Nina |
Marinšek, Matej |
Zagožen, Petra |
Rovan, Ksenija, medicina |
Goslar, Tomaž, 1979- |
Marš, Tomaž, 1972- |
Podbregar, Matej
Teme
Heart Failure, Congestive |
Sulfides |
Blood |
Pulmonary Artery |
Blood Pressure |
Systole |
Patient Readmission |
Treatment Outcome |
Pljučna arterija |
Sistola |
Srce, odpoved kongestivna |
Sulfidi |
Krvni pritisk |
Bolnik, ponovni sprejem v bolnišnico |
Zdravljenje, izid
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Baze podatkov, v katerih je revija indeksirana
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Kovačić, Dragan | 28520 |
Glavnik, Nina | ![]() |
Marinšek, Matej | 28521 |
Zagožen, Petra | ![]() |
Rovan, Ksenija, medicina | ![]() |
Goslar, Tomaž, 1979- | 29975 |
Marš, Tomaž, 1972- | 16345 |
Podbregar, Matej | 21806 |
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