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  • The cytochromes P450 of Grosmannia clavigera : genome organization, phylogeny, and expression in response to pine host chemicals
    Lah, Ljerka, 1976- ...
    Grosmannia clavigera is a fungal associate of the mountain pine beetle (Dendroctonus ponderosae) and a pathogen of lodgepole pine (Pinus contorta) that must overcome terpenoid oleoresin and phenolic ... defenses of host trees. G. clavigera responds to monoterpene influx with complementary mechanisms thatinclude export and the use of these compounds as a carbon source. Cytochromes P450 (CYPs) may also be involved in the metabolism of host defensecompounds. We have identified and phylogenetically classified G. clavigera CYPs (CYPome). We show that although the G. clavigera CYPome has contracted in evolution, certain CYP families have expanded by duplication. Weanalyzed RNA-seq data for CYP expression following treatment with terpenes and pine phloem extracts to identify CYPs potentially involved in detoxification of these pine defense compounds. We also used transcriptome analysis of G. clavigera grown on monoterpenes, triglycerides or oleic acid asa carbon source to identify up-regulated CYPs that may be involved in the utilization of these compounds to support fungal growth. Finally, we identify secondary metabolite biosynthetic gene clusters that contain CYPs, and CYPs inclusters that may be involved in conversion of host chemicals.
    Vir: Fungal genetics and biology. - ISSN 1087-1845 (Vol. 50, 2013, str. 72-81)
    Vrsta gradiva - članek, sestavni del
    Leto - 2013
    Jezik - angleški
    COBISS.SI-ID - 30257113
    DOI

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