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Persistence of late substantial patient-reported symptoms (LAPERS) after radiochemotherapy including image guided adaptive brachytherapy for locally advanced cervical cancer : a report from the EMBRACE studyVittrup, Anders S. ...This report describes the persistence of late substantial treatment-related patient-reported symptoms (LAPERS) in the multi-institutional EMBRACE study on magnetic resonance image guided adaptive ... brachytherapy in locally advanced cervical cancer (LACC). Methods and materials: Patient-reported symptoms (European Organization for Research and Treatment of Cancer [EORTC]-C30/CX24) and physician-assessed morbidity (Common Terminology Criteria for Adverse Events [CTCAE], version 3.0) were assessed at baseline and regular timepoints during follow-up. Patients with sufficient EORTC follow-up (baseline and %3 late follow-up visits) were analyzed. LAPERS events were defined as the presence of substantial EORTC symptoms (quite a bit/very much) for at least half of the assessments (persistence) and progression beyond baseline condition (treatment-related). For each EORTC symptom, the ratio between LAPERS rates and crude incidence rates of substantial symptoms was calculated to represent the proportion of symptomatic patients with persisting symptoms. For 9 symptoms with a corresponding EORTC/CTCAE assessment, the overlap of LAPERS and severe morbidity events (grades 3-5) was evaluated. Results: Of 1047 patients with EORTC available, 741 had sufficient follow-up for the LAPERS analyses. The median follow-up was 59 months (interquartile range, 42-70 months). Across all symptoms, the proportion of patients with LAPERS events (LAPERS rates) was in median 4.6% (range, 0.0% vaginal bleeding to 20.4% tiredness). Urinary frequency, neuropathy, fatigue, insomnia, and menopausal symptoms revealed LAPERS rates of >10%. Vomiting, blood in stool, urinary pain/burning, and abnormal vaginal bleeding displayed LAPERS rates of <1%. A median of 19% of symptomatic patients (interquartile range, 8.0%-28.5%) showed persistent long-term symptoms (LAPERS events). In symptoms with a corresponding EORTC/CTCAE assessment, 12% of LAPERS events were accompanied by a severe CTCAE event. Conclusions: Within this large cohort of survivors of LACC, a subgroup of patients with persistent symptoms (LAPERS events) was identified. For symptoms with a corresponding EORTC/CTCAE assessment, the vast majority of LAPERS events occurred in patients without corresponding severe physician-assessed morbidity. These findings emphasize the importance of distinguishing between transient and persisting symptoms in the aftercare of LACC survivors.Vir: International journal of radiation oncology, biology, physics. - ISSN 0360-3016 (Vol. 109, iss. 1, Jan. 2021, str. 161-173)Vrsta gradiva - članek, sestavni delLeto - 2021Jezik - angleškiCOBISS.SI-ID - 31709699
Avtor
Vittrup, Anders S. |
Tanderup, Kari |
Bentzen, S. |
Kibsgaard Jensen, Nina Boje |
Spampinato, Sofia |
Fokdal, Lars U. |
Lindegaard, Jacob Christian |
Sturdza, Alina |
Šegedin, Barbara |
Jürgenliemk-Schulz, Ina Maria
Teme
brahiterapija |
radiokemoterapija |
rak materničnega vratu |
brachytherapy |
radiochemotherapy |
cervical cancer
vir: International journal of radiation oncology, biology, physics. - ISSN 0360-3016 (Vol. 109, iss. 1, Jan. 2021, str. 161-173)
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Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vittrup, Anders S. | |
Tanderup, Kari | |
Bentzen, S. | |
Kibsgaard Jensen, Nina Boje | |
Spampinato, Sofia | |
Fokdal, Lars U. | |
Lindegaard, Jacob Christian | |
Sturdza, Alina | |
Šegedin, Barbara | 27754 |
Jürgenliemk-Schulz, Ina Maria |
Vir: Osebne bibliografije
in: SICRIS
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