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  • Tissue-type plasminogen activator after venous occlusion in pregnancy and puerperium
    Stegnar, Mojca ...
    Pregnancy is associated with depressed fibrinolysis as judged from the decreased fibrinolytic response to venous occlusion. In order to elucidate if this decreased response is due to an increase in ... plasminogen activator inhibitors 1 and 2 (PAI-1, PAI-2), and/or to decreased release of tissue-type plasminogen activator (t-PA) antigen during venous occlusion, 36 women (18 women with normal pregnancy and 18 with gestational hypertension without proteinuria) were followed during pregnancy and puerperium. In each women a 20min venous occlusion was performed in the second and in the third trimester of pregnancy and 3 days after delivery. The increase in t-PA antigen after venous occlusion relative to basal value was in the second trimester of pregnancy on average 3.7 fold, in the third trimester 4.4 fold, and so not reduced compared to non-pregnant women (3.7 fold increase). After delivery theincrease in t-PA antigen was significantly enhanced (8.5 fold, p less th. 0.005). The fibrinolytic response to venous occlusion measured by euglobulin and t-PA activity was significantly decreased in the third trimester compared to non-pregnant values (both p less th. 0.005) and returned to somewhat higher(euglobulin clot lysis) or significantly higher (t-PA activity, p less th. 0.01) values 3 days after delivery. Decreased euglobulin and t-PA activityafter venous occlusion in the third trimester coincided with significant increases in basal PAI activity, PAI-1 antigen and PAI-2 antigen (2.9, 2.5 and more th. 30 fold increase relative to non-pregnant values, respectively, all p less th. 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)
    Vir: Thrombosis and haemostasis. - ISSN 0340-6245 (Let. 70, št. 3, 1993, str. 486-490)
    Vrsta gradiva - članek, sestavni del
    Leto - 1993
    Jezik - angleški
    COBISS.SI-ID - 31961

vir: Thrombosis and haemostasis. - ISSN 0340-6245 (Let. 70, št. 3, 1993, str. 486-490)
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