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Influence of degraded phosphatidylserine on binding of antiphospholipid antibodiesBožič, Borut, 1959- ...Background: Antiphospholipid antibodies (aPL) show great heterogeneity.r to determine the influence of phospholipid degradation products on the binding ofaPL, sera from 6 patients with the ... antiphospholipid syndrome were studied. Methods: Fresh and aged phosphatidylserine and cardiolipin were used as coating reagents in solid-phase immunoassay procedures. Antiboody reactivity was tested by enzyme-linked immunosorbent assay in the sera and in eluates from columns packed with polystyrene scrapings coated with either cardiolipin or phoshatidylserine. Results: Three reaction patterns of affiniity-purifiied antibodies were seen: (1) reactivity with phosphatidylserine but not with cardiolipin or degraded phosphatidylserine, (2) reactivity with cardiolipin and degraded phosphatidlyserine, and (3) reactivity with all three phospholipid antigens. Conclusions: Striking differences in the antiphospholipid antibody reactivity with cardiolipin, phosphatidylserine and degraded phosphatidylserine in the presence of serum proteins were observed amoong patients with venous Diferent phospholipids, with or without protein cofactor(s), and phospholipid binding proteins alone have been proposed as the target molecules for aPL. InVir: International archives of allergy and immunology. - ISSN 1018-2438 (Let. 112, 1997, str. 19-26)Vrsta gradiva - članek, sestavni delLeto - 1997Jezik - angleškiCOBISS.SI-ID - 34009
Avtor
Božič, Borut, 1959- |
Kveder, Tanja |
Stegnar, Mojca |
Morosini-Berus, Evridika, 1962- |
Golja, Mojca, 1943- |
Peternel, Polona |
Rozman, Blaž, 1944-
Teme
Antibodies, antiphospholipid |
Metabolism |
Antiphospholipid syndrome |
Metabolism |
Phosphatidylserines |
Metabolis |
Cardiolipins |
Metabolism |
Chromatography, high pressure liquid |
Chromatography, affinity |
Chromatography, thin layer |
Enzyme-linked immunosorbent assay |
IGG |
Analysis |
IGM |
analysis |
Human
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Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Božič, Borut, 1959- | 00781 |
Kveder, Tanja | 02066 |
Stegnar, Mojca | 05034 |
Morosini-Berus, Evridika, 1962- | 13507 |
Golja, Mojca, 1943- | 15477 |
Peternel, Polona | 02112 |
Rozman, Blaž, 1944- | 07180 |
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