VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
-
Characterization and risk association of polymorphisms in Aurora kinases A, B and C with genetic susceptibility to gastric cancer development [Elektronski vir]Mesić, Aner ...Background: Single nucleotide polymorphisms (SNPs) in genes encoding mitotic kinases could influence development and progression of gastric cancer (GC). Methods: Case-control study of nine SNPs in ... mitotic genes was conducted using qPCR. The study included 116 GC patients and 203 controls. In silico analysis was performed to evaluate the effects of polymorphisms on transcription factors binding sites. RESULTS: The AURKA rs1047972 genotypes (CT vs. CC: OR, 1.96; 95% CI, 1.05-3.65; p=0.033; CC+TT vs. CT: OR, 1.94; 95% CI, 1.04-3.60; p=0.036) and rs911160 (CC vs. GG: OR, 5.56; 95% CI, 1.24-24.81; p=0.025; GG+CG vs. CC: OR, 5.26; 95% CI, 1.19-23.22; p=0.028), were associated with increased GC risk, whereas certain rs8173 genotypes (CG vs. CC: OR, 0.60; 95% CI, 0.36-0.99; p=0.049; GG vs. CC: OR, 0.38; 95% CI, 0.18-0.79; p=0.010; CC+CG vs. GG: OR, 0.49; 95% CI, 0.25-0.98; p=0.043) were protective. Association with increased GC risk was demonstrated for AURKB rs2241909 (GG+AG vs. AA: OR, 1.61; 95% CI, 1.01-2.56; p=0.041) and rs2289590 (AC vs. AA: OR, 2.41; 95% CI, 1.47-3.98; p=0.001; CC vs. AA: OR, 6.77; 95% CI, 2.24-20.47; p=0.001; AA+AC vs. CC: OR, 4.23; 95% CI, 1.44-12.40; p=0.009). Furthermore, AURKC rs11084490 (GG+CG vs. CC: OR, 1.71; 95% CI, 1.04-2.81; p=0.033) was associated with increased GC risk. A combined analysis of five SNPs, associated with an increased GC risk, detected polymorphism profiles where all the combinations contribute to the higher GC risk, with an OR increased 1.51-fold for the rs1047972(CT)/rs11084490(CG+GG) to 2.29-fold for the rs1047972(CT)/rs911160(CC) combinations. In silico analysis for rs911160 and rs2289590 demonstrated that different transcription factors preferentially bind to polymorphic sites, indicating that AURKA and AURKB could be regulated differently depending on the presence of particular allele. Conclusions: Our results revealed that AURKA (rs1047972 and rs911160), AURKB (rs2241909 and rs2289590) and AURKC (rs11084490) are associated with a higher risk of GC susceptibility. Our findings also showed that the combined effect of these SNPs may influence GC risk, thus indicating the significance of assessing multiple polymorphisms, jointly. The study was conducted on a less numerous but ethnically homogeneous Bosnian population, therefore further investigations in larger and multiethnic groups and the assessment of functional impact of the results are needed to strengthen the findings.Vir: BMC cancer [Elektronski vir]. - ISSN 1471-2407 (Vol. 19, no. 1, 2019, str. 1-14)Vrsta gradiva - e-članekLeto - 2019Jezik - angleškiCOBISS.SI-ID - 34473433
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|---|
Mesić, Aner | ![]() |
Rogar, Marija, 1983-2024 | 34353 |
Hudler, Petra, 1976- | 21395 |
Bilalović, Nurija | ![]() |
Eminović, Izet | 22965 |
Komel, Radovan | 06135 |
Vir: Osebne bibliografije
in: SICRIS
Izberite prevzemno mesto:
Prevzem gradiva po pošti
Naslov za dostavo:
Med podatki člana manjka naslov.
Storitev za pridobivanje naslova trenutno ni dostopna, prosimo, poskusite še enkrat.
S klikom na gumb "V redu" boste potrdili zgoraj izbrano prevzemno mesto in dokončali postopek rezervacije.
S klikom na gumb "V redu" boste potrdili zgoraj izbrano prevzemno mesto in naslov za dostavo ter dokončali postopek rezervacije.
S klikom na gumb "V redu" boste potrdili zgoraj izbrani naslov za dostavo in dokončali postopek rezervacije.
Obvestilo
Trenutno je storitev za avtomatsko prijavo in rezervacijo nedostopna. Gradivo lahko rezervirate sami na portalu Biblos ali ponovno poskusite tukaj kasneje.
Gesla v Splošnem geslovniku COBISS
Izbira mesta prevzema
Gradivo iz matične enote je brezplačno. Če je gradivo na mesto prevzema dostavljeno iz drugih enot, lahko knjižnica to storitev zaračuna.
Mesto prevzema | Status gradiva | Rezervacija |
---|
Rezervacija v teku
Prosimo, počakajte trenutek.
Rezervacija je uspela.
Rezervacija ni uspela.
Rezervacija...
Članska izkaznica:
Mesto prevzema: