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  • Roxithromycin-loaded lipid nanoparticles for follicular targeting
    Wosicka-Frąckowiak, Hanna ...
    Particulate drug carriers e.g. nanoparticles (NPs) have been shown to penetrate and accumulate preferentially in skin hair follicles creating high local concentration of a drug. In order to develop ... such a follicle targeting system we obtained and characterized solid lipid nanoparticles (SLN) loaded with roxithromycin (ROX). The mean particle size (172 +- 2 nm), polydisperisty index (0.237 +- 0.007), zeta potential (-31.68 +- 3.10 mV) and incorporation efficiency (82.1 +- 3.0%) were measured. The long term stability of ROX-loaded SLN suspensions was proved up to 26 weeks. In vitro drug release study was performed using apparatus 4 dialysis adapters. Skin irritation test conducted using the EpiDermŽ tissue model demonstrated no irritation potential for ROX-loaded SLN. Ex vivo human skin penetration studies, employing rhodamine B hexyl ester perchlorate (RBHE) as a fluorescent dye to label the particles, revealed fluorescence deep in the skin, specifically around the hair folliclesup to over 1 mm depth. The comparison of fluorescence intensities after application of RBHE solution and RBHE-labelled ROX-loaded SLN was done. Then cyanoacrylate follicular biopsies were obtained in vivo and analyzed for ROX content, proving the possibility of penetration to human pilosebaceous units and delivering ROX by using SLN with the size below 200 nm.
    Vir: International journal of pharmaceutics. - ISSN 0378-5173 (Vol. 495, iss. 2, 2015, str. 807-815)
    Vrsta gradiva - članek, sestavni del ; neleposlovje za odrasle
    Leto - 2015
    Jezik - angleški
    COBISS.SI-ID - 3958385

    Povezava(-e):

    http://www.sciencedirect.com/science/article/pii/S0378517315302672
    DOI

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