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  • Investigation of the influence of solid carriers on resveratrol release from solid SMEDDS : mestrado integrado em ciências farmacêuticas
    Firmino Carvalho Nunes de Carvalho, Duarte
    Poorly water-soluble active pharmaceutical ingredients (API) constitute nowadays a challenge for pharmaceutics, as they represent a relevant portion of the available drugs. They are often subject to ... an only partial dissolution or may even precipitate throughout the intestine route, leading to a variable bioavailability. To overcome this inefficient absorption, different approaches can be taken into account. Self-microemulsifying drugs delivery systems (SMEDDS) constitute an example of formulations used to improve the absorption of such APIs. These systems are isotropic mixtures composed by oil, surfactants/co-surfactants and a drug, which spontaneously form a nano- or microemulsion when agitated with water present. They improve the absorption of the incorporated drug by maintaining the API in a solubilized state during its intestinal passage. In order to overcome the drawbacks of liquids, approaches to convert liquid SMEDDS into solid dosage forms with self-microemulsifying properties are extensively investigated. The aim of the present research was, from a previously developed liquid SMEDDS formulation containing resveratrol, alter it into solid state by spray drying technique and compare solid carriers for this formulation. The three different solid carriers compared were Neusilin US2 (a magnesium aluminometasilicate), Syloid 244 FP and Sylysia 350 (silicas). All these materials have in common the high adsorbing ability, making them capable of taking great amounts of water or oils. In this work, the comparison was made through dissolution studies. The dissolution studies established Neusilin US2 as the superior carrier for this formulation between the three, reaching a drug release of almost 90% after 8 hours in an intestine mimicked medium. On the other hand, Syloid 244 FP and Sylysia 350 provided poorer results, standing behind the liquid SMEDDS formulation. In a gastric environment the results were somewhat parallel, although the ratio of drug released was lower. In conclusion, this research showed promising results that indicated SMEDDS usefulness in the application of poorly water-soluble drugs. A successful formulation was prepared, obtaining encouraging results in what concerns drug release rates in physiological environments.
    Vrsta gradiva - magistrsko delo ; neleposlovje za odrasle
    Založništvo in izdelava - Lisboa : [D. Firmino Carvalho Nunes de Carvalho], 2015
    Jezik - angleški
    COBISS.SI-ID - 4108913

Nobena knjižnica v sistemu COBISS.SI nima izvoda tega gradiva.
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