Solid nanoparticles (SLN) are an alternative particulate drug carrier system to polymeric nanoparticles, liposomes and fat emulsions. The aim of our study was to prepare SLN of different lipid by the ...melt-emulsification process and estimate their stability. In order to find the optimal procedure, several dynamic parameters were varied, including emulsification (time, stirring rate) and cooling conditions. Additionally, the effect of phosholipid concentration on the mean diameter and zete potential of SLN was examined, Particles were characterised by mean size, polydispersity index and zeta potential measurements. The mean size of the lipid nanoparticles determined by photon correlation spectrosocopy varied from 120 to 220 nm depending on the procedure parameters and composition of the lipid matrix. We have found that the viscosity of lipid melts affects the SLN size less than the procedure parameters. The optimum procedure parameters need to be assessed for each nanoparticle system separetely. The obtained results indicate that Witepsol and Dynansa SLN remain stable at 4°C since no pronounced particle growth could be detected over the monitored period. On the contrary, Compritol SLN dispersion are remarkably unstable since the mean particle size increased from155 nm to [micro]m eithin one-week incubation period. Phospholipids have a specific influence on the formation of SLN. In 1-2%(m/m) concentration, the stable SLN dispersion is formed, and a higher phospholipid concentrations the liposome formation was stated as well.
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