VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
-
MiR-148a the epigenetic regulator of bone homeostasis is increased in plasma of osteoporotic postmenopausal womenBedene, Ajda ...Background: Osteoporosis is a prevalent skeletal disorder characterized by reduced bone mineral density and microarchitectural deterioration of bone tissue, resulting in bone fragility and low trauma ... fractures. Imaging techniques are used routinely to detect low bone mass; however, they are unable to identify deterioration of bone quality. Recently, microRNAs have emerged as regulators of bone remodelling and potentially also as a new class of sensitive biomarkers of bone health to aid in diagnosis and treatment monitoring of osteoporosis. Methods: To identify new plasma-based biomarkers associated with osteoporosis we analysed microRNAs isolated from plasma samples of 74 postmenopausal women divided into osteoporotic (N=17) and control groups (N=57). A prior microRNA screening was performed where a few showed promise for further analysis. Quantitative polymerase chain reaction was used to investigate differences in expression of let-7d-5p, let-7e-5p, miR-30d-5p, miR-30e-5p, miR-126-3p, miR-148a-3p, miR-199a-3p, miR-423-5p and miR-574-5p, between the two groups. Furthermore, correlation analysis between miRNA expression levels and patient bone mineral density measurements and FRAX as well as trabecular bone scores were performed. Results: Expression of miR-148a-3p was significantly higher (p = 0.042) in the osteoporotic patient group compared to the control. In addition, we identified a correlation between miR-126-3p ([ro] = 0.253, p = 0.032) and 423-5p ([ro] = 0.230, p = 0.049) and parameters of bone quality and quantity. Conclusion: Results from our study, together with the functional role of miR-148a-3p in bone suggest, that this miRNA could be considered as a potential new plasma-based biomarker for pathological changes associated with osteoporosis.Vir: Wiener Klinische Wochenschrift. - ISSN 0043-5325 (Vol. 128, suppl. 7, 2016, str. 519-526)Vrsta gradiva - članek, sestavni delLeto - 2016Jezik - angleškiCOBISS.SI-ID - 4247153
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|---|
Bedene, Ajda | ![]() |
Mencej Bedrač, Simona | 24475 |
Ješe, Lea | ![]() |
Marc, Janja | 12189 |
Vrtačnik, Peter, 1984- | 32807 |
Preželj, Janez | 01989 |
Kocjan, Tomaž, 1966- | 15783 |
Kranjc, Tilen | 33053 |
Ostanek, Barbara, 1972- | 18154 |
Vir: Osebne bibliografije
in: SICRIS
Izberite prevzemno mesto:
Prevzem gradiva po pošti
Naslov za dostavo:
Med podatki člana manjka naslov.
Storitev za pridobivanje naslova trenutno ni dostopna, prosimo, poskusite še enkrat.
S klikom na gumb "V redu" boste potrdili zgoraj izbrano prevzemno mesto in dokončali postopek rezervacije.
S klikom na gumb "V redu" boste potrdili zgoraj izbrano prevzemno mesto in naslov za dostavo ter dokončali postopek rezervacije.
S klikom na gumb "V redu" boste potrdili zgoraj izbrani naslov za dostavo in dokončali postopek rezervacije.
Obvestilo
Trenutno je storitev za avtomatsko prijavo in rezervacijo nedostopna. Gradivo lahko rezervirate sami na portalu Biblos ali ponovno poskusite tukaj kasneje.
Gesla v Splošnem geslovniku COBISS
Izbira mesta prevzema
Gradivo iz matične enote je brezplačno. Če je gradivo na mesto prevzema dostavljeno iz drugih enot, lahko knjižnica to storitev zaračuna.
Mesto prevzema | Status gradiva | Rezervacija |
---|
Rezervacija v teku
Prosimo, počakajte trenutek.
Rezervacija je uspela.
Rezervacija ni uspela.
Rezervacija...
Članska izkaznica:
Mesto prevzema: