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  • Development of software to aid in the optimization of elemental imaging by LA-ICP-MS
    Triglav, Jure, 1986- ; Elteren, Johannes Teun van ; Šelih, Vid Simon
    LA-ICP-MSsystem is a robust sampling technique for elemental analysis of various inorganicand organic materials.The microbeamcapabilities of the laser enable us to perform virtually non-destructive ... microanalysis for spatial resolution purposes (surface mapping and depth profiling) in the low mg kg-1range for most elements of the periodic table. Using a 213 nm Nd-YAG laserwith adjustable laser beam characteristics, coupled to a quadrupole ICP-MS, real-time elemental detection is possible, allowing rastering of a samplefor elementalmappingpurposes. Elemental mapping is prone to all kind of challenges, which may be related to the critical parameters sensitivity, resolution, noise and analysis time. Optimising the elemental mapping process is usually a matter of trial and error since all parameters are dependent of each other. A theoretical model we developed links these parameters to the LA-ICP-MS input settings (energy density, pulse rate, beam diameter, scanning speed, acquisition time) to get insight into the interactions of these settings with the fundamentalanalytical parameters. By careful assessment of the model we learnt that post-analysis resolution enhancementis possible usingthe model in reversemode or even by usinga genetic algorithm that runs through a process of simulated evolution. However,this can only be achieved with the development of dedicated software, enabling us to quickly comparethese approachesand study the influenceof various LA-ICP-MS settings on the image quality in asimulated rastering procedure.This presentation will focus on the use of computer programmingto aid in the optimization of elemental imaging by LA-ICP-MS.
    Vir: Book of abstracts : YISAC 2010 (Str. 7)
    Vrsta gradiva - prispevek na konferenci
    Leto - 2010
    Jezik - angleški
    COBISS.SI-ID - 4455450

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