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Impact of buffer, protein concentration and sucrose addition on the aggregation and particle formation during freezing and thawing [Elektronski vir]Hauptmann, Astrid ...This study addresses the effect of freezing and thawing on a therapeutic monoclonal antibody (mAb) solution and the corresponding buffer formulation. Particle formation, crystallization behaviour, ... morphology changes and cryo-concentration effects were studied after varying the freezing and thawing rates, buffer formulation and protein concentration. The impact of undergoing multiple freeze/thaw (FT)-cycles at controlled and uncontrolled temperature rates on mAb solutions was investigated in terms of particle formation. Physicochemical characteristics were analysed by Differential Scanning Calorimetry whereas morphology changes are visualized by cryomicroscopy measurements. Micro Flow Imaging, Archimedes and Dynamic Light Scattering were used to investigate particle formation. Data retrieved in the present study emphasizes the damage caused by multiple FT-cyles and the need for sucrose as a cryoprotectant preventing cold-crystallization specifically at high protein concentrations. Low protein concentrations cause an increase of micron particle formation. Low freezing rates lead to a decreased particle number with increased particle diameter. The overall goal of this research is to gain a better understanding of the freezing and thawing behaviour of mAb solutions with the ultimate aim to optimize this process step by reducing the unwanted particle formation, which also includes protein aggregates.Vir: Pharmaceutical research. - ISSN 1573-904X (Vol. 35, iss. 5, Mar. 2018, str. 1-16)Vrsta gradiva - e-članekLeto - 2018Jezik - angleškiCOBISS.SI-ID - 4491889
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Hauptmann, Astrid | ![]() |
Podgoršek, Katja | ![]() |
Kuzman, Drago | 18355 |
Srčič, Stanko | 09031 |
Hölzl, Georg | ![]() |
Loerting, Thomas | ![]() |
Vir: Osebne bibliografije
in: SICRIS
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