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  • Catalytic approach to diverse▫$alpha$▫-aminoboronic acid derivatives by iridium-catalyzed hydrogenation of trifluoroborate-iminiums
    Šterman, Andrej, farmacevt ...
    A series of structurally diverse benzyl protected trifluoroborate-ammoniums were prepared in good to high yields by an efficient hydrogenation of corresponding trifluoroborate-iminiums using ... Crabtree's catalyst. Subsequent N- and B-deprotections were demonstrated on selected examples to provide several alpha]-aminoboronic acids. Preliminary experiments on asymmetric version of the reaction indicated a correlation between E/Z-ratio in the trifluoroborate-iminium substrate and enantioselectivity. The broad scope, operational simplicity and efficiency of the presented method imply its high potential for a facile access to libraries of [alpha]-aminoboronic acid derivatives that can be used in medicinal chemistry applications and beyond.
    Vir: Advanced Synthesis & Catalysis [Elektronski vir]. - ISSN 1615-4169 (Vol. 363, iss. 9, 2021, str. 2396-2402)
    Vrsta gradiva - e-članek
    Leto - 2021
    Jezik - angleški
    COBISS.SI-ID - 48204803

    Povezava(-e):

    https://onlinelibrary.wiley.com/doi/full/10.1002/adsc.202001350
    DOI

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