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  • Synthesis and pharmacological activity of O-aminoalkyl derivatives of 7-hydroxycoumarin
    Trykowska Konc, Joanna ...
    A series of novel O-aminoalkyl substituted 7-hydroxycoumarins were synthesizedand evaluated for antibacterial and anticancer toxicity. Two different synthetic procedures, conventional and microwave ... assisted were used,and the structures of the compounds were confirmed by IR, 1H, 13C NMR andMAS spectroscopic data. The molecular and crystal structures of 8-acetyl-7-[2-(1-morpholino)ethoxy]4-methylchromen-2-one in solid state were analyzed by single crystal X-ray diffraction. The compound crystallizes in themonoclinic space group P21/c. The main driving forces for the supramolecular structure are the C-H?O hydrogen bonds and the [pi]...[pi] intermolecular interactions. The most active compounds are those, where the O-aminoalkyl substituent has N,N-diethylamino part, and acetyl group is at C6 or at C8 atoms.
    Vir: European journal of medicinal chemistry. - ISSN 0223-5234 (Vol. 46, iss. 6, 2011, str. 2252-2263)
    Vrsta gradiva - članek, sestavni del
    Leto - 2011
    Jezik - angleški
    COBISS.SI-ID - 4892442

    Povezava(-e):

    http://www.sciencedirect.com/science/article/pii/S022352341100208X

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