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  • An organoruthenium anticancer agent shows unexpected target selectivity for plectin
    Meier, Samuel M. ...
    Organometallic metal(arene) anticancer agents require ligand exchange for their anticancer activity and this is generally believed to confer low selectivity for potential cellular targets. However, ... using an integrated proteomics-based target-response profiling approach as a potent hypothesisgenerating procedure, we found an unexpected target selectivity of a ruthenium(arene) pyridinecarbothioamide (plecstatin) for plectin, a scaffold protein and cytolinker, which was validated in a plectin knock-out model in vitro. Plectin targeting shows potential as a strategy to inhibit tumor invasiveness as shown in cultured tumor spheroids while oral administration of plecstatin- 1 to mice reduces tumor growth more efficiently in the invasive B16 melanoma than in the CT26 colon tumor model.
    Vir: Angewandte Chemie : International edition. - ISSN 1433-7851 (Vol. 56, iss. 28, 2017, str. 8267-8271)
    Vrsta gradiva - članek, sestavni del ; neleposlovje za odrasle
    Leto - 2017
    Jezik - angleški
    COBISS.SI-ID - 57696003

    Povezava(-e):

    https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201702242
    DOI

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