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  • The efficacy, safety and tolerability of canakinumab in the treatment of familial Mediterranean fever [Elektronski vir] : a systematic review of the literature
    Kačar, Mark ; Savic, Sinisa ; van der Hilst, Jeroen CH
    Familial Mediterranean Fever (FMF) is the most prevalent genetic autoinflammatory disorder. In most patients, treatment with colchicine can prevent attacks of fever and inflammation. However, 5%-10% ... of patients are resistant to colchicine treatment, while a similar percentage cannot tolerate colchicine in doses needed to prevent attacks. For these patients, Canakinumab, a full human antibody against IL-1[beta], has been approved recently by the FDA and EMA. In this article, we present a systematic review of the long-term efficacy, safety, and tolerability of Canakinumab in FMF patients who cannot tolerate colchicine or who are resistant to colchicine treatment.
    Vir: Journal of inflammation research. - ISSN 1178-7031 (Vol. 13, 9 Mar. 2020, str. 141-149)
    Vrsta gradiva - e-članek ; neleposlovje za odrasle
    Leto - 2020
    Jezik - angleški
    COBISS.SI-ID - 58075139

    Povezava(-e):

    https://www.dovepress.com/getfile.php?fileID=56642
    DiRROS - Digitalni repozitorij raziskovalnih organizacij Slovenije
    DOI

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