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Distribution of human papillomavirus genotypes in women with high-grade cervical intraepithelial lesions and cervical carcinoma and analysis of human papillomavirus-16 genomic variantsKaradža, Magdalena ...Aim: To analyze the distribution of high-risk human papillomavirus (HR-HPV) genotypes and the diversity of HPV-16 genomic variants in Croatian women with high-grade squamous intraepithelial lesions ... (HSIL) and cervical carcinoma. Methods: Tissue biopsy specimens were obtained from 324 women with histopathologically confirmed HSIL or cervical carcinoma, 5 women with low-grade SIL, and 49 women with negative histopathology. HR-HPV DNA was detected with Ampliquality HPV-type nucleic-acid hybridization assay, which identifies 29 different HPV genotypes. HPV-16 genomic variants were analyzed by an in-house sequencing. Results: The most common HPV type in women with HSIL was HPV-16, detected in 127/219 (57.9%) specimens. HPV-16 was also the dominant type in squamous cell cervical carcinoma (46/69 or 66.7%) and in adenocarcinoma (18/36 or 50.0%). Out of 378 patients, 360 had HR-HPV (282 single infections and 79 multiple infections), 3 (0.8%) patients had low-risk HPV, and 15 (4%) tested negative. HPV-16 variants were determined in 130 HPV-16 positive specimens, including 74 HSIL and 46 carcinoma specimens. In HSIL specimens, 41 distinct variants were found, 98.6% belonging to the European branch and 1.4% belonging to the African branch. In cervical carcinoma specimens, 95% isolates grouped in 41 variants belonging to the European branch, one isolate (2.5%) belonged to the North American, and one (2.5%) to the Asian-American branch. Conclusion: HPV-16, mainly belonging to the European branch, was the most frequent HPV genotype in women from Croatia with histologically confirmed HSIL and cervical cancer.Vir: Croatian medical journal. - ISSN 0353-9504 (Vol. 62, iss. 1, 2021, str. 68-79)Vrsta gradiva - članek, sestavni del ; neleposlovje za odrasleLeto - 2021Jezik - angleškiCOBISS.SI-ID - 60703235
Avtor
Karadža, Magdalena |
Židovec-Lepej, Snježana |
Planinić, Ana |
Grgić, Ivana, zdravnica |
Ćorušić, Ante |
Planinić, Pavao |
Čorić, Mario |
Hošnjak, Lea |
Fujs Komloš, Kristina |
Poljak, Mario, 1965- |
Vince, Adriana
Teme
human papillomavirus |
cervical carcinoma |
genomic variants |
humani papiloma virus |
karcinom materničnega vratu |
genomske variante
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Karadža, Magdalena | ![]() |
Židovec-Lepej, Snježana | ![]() |
Planinić, Ana | ![]() |
Grgić, Ivana, zdravnica | ![]() |
Ćorušić, Ante | ![]() |
Planinić, Pavao | ![]() |
Čorić, Mario | ![]() |
Hošnjak, Lea | 38525 |
Fujs Komloš, Kristina | 25986 |
Poljak, Mario, 1965- | 11622 |
Vince, Adriana | ![]() |
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