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Reliability of data from proxy respondents in an international case-control study of cardiovascular disease and oral contraceptivesPoulter, N... R... ...Study objectives. To evaluate the reliability of data supplied in a case-control study by proxy respondents for cases who were too ill to do so themselves. Design. A hospital based, case-control ... study of the current use oforal contraceptives (OC) and cardiovascular diseases. Data from "true" controls matched to a subset of cases were compared with those supplied by proxy respondents about the true controls. Setting. Hospitals in 21 centres from Africa, Asia, Europe, and Latin America. Patients and participants. For asubset of cases, 403 pairs of controls - one "true" and one proxy - were interviewed. "True" controls were matched by age, place, and time of admissionand were admitted with 1 of 27 permissible diagnoses not associated with O use. Proxy controls were either relatives or friends of true controls. Main results. Levels of concordance between data from proxy and true controls were high for most variables regarding recent events, including current OC use, but were greatly diminished when detailed information, particularly from the past, was required. Husbands were usually the best proxy, although this was questionspecific. The sensitivity and specificity of proxy responses were 93% (95% confidence intervals: 77%, 99%) and 100% (98%, 100%) respectively, for current use of OC. Assuming the misclassification of current OC use by proxy cases is similar to that produced bu proxy controls, the estimated impact of using proxy data on risk estimates associated with current OC use was to bias the overall estimate of risk of stroke by less than 3% and the risks of both acute myocardial infarction and venous thromboembolism by less than 1%. Conclusions. Friends or relatives, and particularly husbands, provided reliable information when used as proxy respondents for young women. The estimated impact of misclassification by proxy respondents on overall riskestimates in the WHO collaborative study was less than (Abstract truncatedat 2000 characters).Vir: Journal of epidemiology and community health. - ISSN 0141-7681 (Let. 50, 1996, str. 674-680)Vrsta gradiva - članek, sestavni delLeto - 1996Jezik - angleškiCOBISS.SI-ID - 6769881
Avtor
Poulter, N... R... |
Chang, C... L... |
Farley, T. M... M... |
Marmot, M... G... |
Kožuh-Novak, Mateja
Drugi avtorji
World health organization collaborative study of cardiovascular disease and steroid hormone contraception
Teme
Contraceptives, oral |
Adverse effects |
Cardiovascular diseases |
Etiology |
Case-control studies |
Human |
Female |
Africa |
Asia |
Europe |
Latin America
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Kožuh-Novak, Mateja | 03354 |
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