VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
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Urinary extracellular vesicles and their miRNA cargo in patients with Fabry nephropathy [Elektronski vir]Levstek, Tina, farmacevtka ...Current biomarkers of Fabry nephropathy lack sensitivity in detecting early kidney damageand do not predict progression of nephropathy. Urinary extracellular vesicles (uEVs) and theirmolecular cargo ... could reflect early changes in renal impairment as they are secreted by the cellslining the urinary tract. We aimed to conduct a proof-of-concept study to investigate whether analysisof uEV characteristics and expression of uEV-derived microRNAs (miRNAs) could be applicablein studies to predict the development and progression of nephropathy in Fabry disease. A totalof 20 Fabry patients were divided into two groups, depending on the presence of nephropathy.Chronological urine samples collected during 10-year follow-up were used for uEVs isolation withsize exclusion chromatography. Nanoparticle tracking analysis was used to determine concentrationand size of uEVs. We evaluated the expression of five uEV-derived miRNAs by qPCR (miR-23a-3p,miR-29a-3p, miR-30b-5p, miR-34a-5p, miR-200a-3p). There was no difference in the concentrationand size of uEVs between patients with and without nephropathy at last follow-up or longitudinally.However, we found increased expression of miR-29a-3p and miR-200a-3p in uEVs isolated fromchronological samples of patients with Fabry nephropathy. This may indicate an attempt by theorganism to prevent the progression of renal damage leading to end-stage renal disease as previouslyreported in type 1 diabetes. In addition, we found an increased expression of miR-30b-5p in the10-year period in uEVs of patients without renal dysfunction. miR-30b-5 was reported to have aprotective role in podocyte injury and may possibly be important in Fabry nephropathy. Thesefindings indicate that uEVs and their molecular cargo could be a promising target of studies focusingon elucidation of Fabry nephropathy. Nevertheless, total concentration and size of uEVs were neitherindicative of the presence nor progression of Fabry nephropathy, while the role of the analyzedmiRNAs in Fabry nephropathy progression was merely indicated and needs further in-depth studies.Vir: Genes [Elektronski vir]. - ISSN 2073-4425 (Vol. 12, no. 7, 2021, str. 1-15)Vrsta gradiva - e-članekLeto - 2021Jezik - angleškiCOBISS.SI-ID - 70049795
Avtor
Levstek, Tina, farmacevtka |
Mlinšek, Teo |
Holcar, Marija, 1987- |
Goričar, Katja, 1987- |
Lenassi, Metka, 1978- |
Dolžan, Vita |
Vujkovac, Bojan |
Trebušak Podkrajšek, Katarina
Teme
Fabry nephropathy |
urinary extracellular vesicles |
miRNA expression |
Fabryjeva nefropatija |
urinski zunajcelični vezikli |
izražanje miRNA
Vnos na polico
Trajna povezava
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Faktor vpliva
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Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Levstek, Tina, farmacevtka | 53776 |
Mlinšek, Teo | |
Holcar, Marija, 1987- | 33344 |
Goričar, Katja, 1987- | 33110 |
Lenassi, Metka, 1978- | 24288 |
Dolžan, Vita | 11711 |
Vujkovac, Bojan | 34761 |
Trebušak Podkrajšek, Katarina | 20253 |
Vir: Osebne bibliografije
in: SICRIS
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