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  • Regulacija sinteze kolicina K bakterije Escherichia coli in vloga kolicinov : doktorsko delo = Regulation of colicin K expression in Escherichia coli and the role of colicins : dissertation thesis
    Kuhar, Irena
    Escherichia coli strains are part of the normal intestinal flora of humans. However, pathogenic strains often cause intestinal and urinary tract infections and rarely neonatal meningitis and sepsisČ ... Pathogenic E. coli strains can cause infections due to the production of virulence factors such as toxins, adhesins, capsules, invasins, mobility, systems for iron uptake andothers. The synergistic action of everal virulence factors is needed to overcome the hostćs defence mechanisms and to elicit infection. Invasiveness and toxigenicity determine virulence of a pathogen. The relationship between host and pathogen is dynamic, since each modifies the activities and functionsof the other. The outcome of this relationship depends on the pathogenicity of the pathogen, that is, on its ability to inflict damage, and on the resistance of the host. The gastrointestinal flora is a pool of E. colistrains. Pathogenic strains have to compete with other strains, which havethe same nutritional requirements and ability to adhere to the same tissue. To initiate the infection process, a bacterium must establish a habitat and survive in the host. This is mediated among other factors by colicins and fimbrial adhesins. The expression of virulence factors is not constitutive, rather it is regulated with regard to cell physiology and environmental signals. The aim of this thesis was first to determine the potential of intestine strains to cause extraintestinal infection. For this purpose virulence determinants associated with extraintestinal infections in intestinal E. coli was analysed and correlations between individual virulence factors. Further, the regulation of expression of an E. coli bacteriocin, colicin K, found in uropathogenic strain, was studied to get some new insightsinto the regulation of virulence factors and the role colicins have inthe natural environment. (Abstract truncated at 2000 characters).
    Vrsta gradiva - disertacija ; neleposlovje za odrasle
    Založništvo in izdelava - Ljubljana : [I.Kuhar], 2001
    Jezik - slovenski
    COBISS.SI-ID - 714063

Knjižnica/institucija Kraj Akronim Za izposojo Druga zaloga
MF, Centralna medicinska knjižnica, Ljubljana Ljubljana CMK na dom 2 izv.
Nacionalni inštitut za biologijo in BF, Oddelek za biologijo, Ljubljana Ljubljana BFBNIB v čitalnico 1 izv.
Narodna in univerzitetna knjižnica, Ljubljana Ljubljana NUK v čitalnico 1 izv.
Univerzitetna knjižnica Maribor Maribor UKM v čitalnico 1 izv.
ni za izposojo 1 izv.
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