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  • Comparative evaluation of clindamycin/gentamicin and cefoxitin/doxycycline for treatment of pelvic inflammatory disease : a multi-center trial
    Maria, Bernard ...
    The clinical efficacy and safety of clindamycin-gentamicin versus doxycycline-cefoxitin in the treatment of acute pelvic inflammatory disease was evaluated in a comparative, randomized, prospective, ... multicenter study. Ten investigators enrolled 170 patients. Those judged to be eligible for efficacy were 60/88 (68 percent) who received the clindamycin-gentamicin regimen and 55/82 (67 percent) of those treated with cefoxitin-doxycycline. A successful clinical outcome was attained for 52/60 (87 percent) and 46/55 (84 percent) for patients treated with clindamycin-gentamicin and cefoxitin-doxycycline, respectively, a difference that was not statistically significant. In the clindamycin-gentamicin series, 8/8 (100 percent) of patients with positive C. trachomatis culture at baseline were culture negative at the late follow-up 21-35 days after treatment. For those given cefoxitin-doxycycline, 9/11 (82 percent) who had C. trachomatis at pretreatment showed eradication at follow-up. Neisseria gonorrhoeae was present at baseline in 8/60 (13 percent) of the clindamycin-gentamicin patients and in 9/55 (16 percent) of those treated with cefoxitin-doxycycline.Of those who had appropriate follow-up cultures performed, 6 in the clindamycin-gentamicin group and 8 in the cefoxitin-doxycycline series, all showed eradication of the organism. It is concluded that clindamycin-gentamicin and cefoxitin-doxycycline have similar clinical cure rates for acute pelvic inflammatory disease, and based on this limited experience, it is suggested that the clindamycin-gentamicin combination will satisfactorily eradicate Chlamydia trachomatis and Neisseria gonorrhoeae when either or both of these pathogens are present.
    Vir: Acta obstetricia et gynecologica Scandinavica. - ISSN 0001-6349 (Let. 71, št. 2, 1992, str. 129-134)
    Vrsta gradiva - članek, sestavni del
    Leto - 1992
    Jezik - angleški
    COBISS.SI-ID - 7150809

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