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13.
Changes in TGF-beta1 levels in gingiva, crevicular fluid and serum associated with periodontal inflammation in humans and dogs
Skalerič, Uroš, 1945-2023 ...
Transformating growth factor-beta (TGF-beta) represents a family of polypeptide growth factors, involved in embryogenesis, inflammation, regulation of immune responses and wound healing. To determine ...whether TGF-beta contributes to the evolution of periodontal disease, we assayed TGF-beta levels in gingiva and crevicular fluid of patients with gingivitis and periodontitis. In pearallel, TGF-beta was quantified in gingival fluid andserum of beagles with experimentally-inuced periodontitis. Disease was monitored by several clinical parameters including Plaque Index, Gingival Index, probing depth, and epithelial attachment loss. Gingival tissues were obtained from 9 patients at the time of periodontal surgery, and gingival fluid samples were collected from an additional population of 10 periodontal patients. in 14 beagles, experimental periodontitis was induced and gingival fluids collected 6 months later. Fluid was collected by paper strips and volume measured by Periotron. Additionally, sera was collected before and 9 months after the ligature-induced periodontitis in 7 beagles. The levels of TGF-beta1, were measured by ELISA. In the patients, a significantly higher concentration of TGF-beta1 was observed both in the gingival tissues and fluidsamples obtained from the sites with deeper periodontal pockets than in the less involved sites. In beagles, TGF-beta1 levels measured in gingival fluid were elevated in moderate disease, declining in fluid samples obtained from the pockets during more advanced experimental periodontitis. Furthermore,with the progression of experimental periodontitis, a decrease in TGF-beta1 occurred in the sera of the beagle dogs. These data suggest that TGF-beta 1 may play a role in the pathogenesis and diagnosis of periodontal disease, and that its actions can be further explored in an animal model.
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