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  • Venous thromboembolic disease and combined oral contraceptives: results of international multicentre case-control study
    Debert-Ribeiro, Myriam ...
    The composition and use of oral contraceptives (OCs) have changed since their cardiovascular side-effects were established 20 years ago. This report describes the risk of idiopathic venous ... thromboembolic (VTE) events (deep veinthrombosis ŠDVTĆ and/or pulmonary embolism ŠPEĆ) in association with current use of combined OCs among 1143 cases aged 20-44 and 2998 age-matched controls, as evaluated in a hospital-based, case-control study in 21 centres in Africa, Asia, Europe, and Latin America. OC use was associated with an increased risk of VTE in Europe (odds ratio 4.15 Š95 percent CI 3.09-5.57Ć) and in non-European ("developing") countries (3.25 Š2.59-4.08Ć). Risk estimates were generally higher for DVT than for PE but no consistent trend bycertainty of diagnosis (definite, probable, possible) was found. Increased risk was apparent within 4 months of starting OCs, was unaffected by duration of current episode of OC use, and had disappeared within 3 months of stopping OCs. Relative risk estimates of VTE associated with OC use were unaffected by age of user, by history of hypertension (excluding hypertension in pregnancy),or in any consistent way by smoking. However, in both groups of countries increased body mass index (BMI) was an independent risk factor for VTE, and OC-associated odds ratios were higher among those with a BMI above 25kg/m2 than among those with smaller BMIs. OC-associated risk estimates were high among women in Europe with a history of hypertension in pregnancy. Odds ratios associated with the use of OCs containing a third-generation progestagen were higher than those observed with progestagens of the first (norethindrone type) and second (norgestrel group) generation. Odds ratios associated with first and second generation progestagens tended to be lower, though not significantly, when used in combination with low ( less th. 50 micrograms oestrogen) rather than higher oestrogen doses.(trunc.)
    Vir: The Lancet. - ISSN 0140-6736 (Let. 346, št. 8990, 1995, str. 1575-1582)
    Vrsta gradiva - članek, sestavni del
    Leto - 1995
    Jezik - angleški
    COBISS.SI-ID - 7658713

vir: The Lancet. - ISSN 0140-6736 (Let. 346, št. 8990, 1995, str. 1575-1582)
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