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  • Effect of different progestagens in low oestrogen oral contraceptives on venosthromboembolic disease
    Dobert-Ribeiro, Myriam ...
    A multinational hospital-based case-control study of the risk of venous thromboembolic disease associated with combined oral contraceptives (OCs) donein 1989-93 prompted a separate inquiry comparing ... the risk of venous thromboembolism (VTE) associated with low oestrogen ( less th. 35 micrograms ethinyloestradiol) OCs containing levonorgestrel with risks in low oestrogen preparations containing the third-generation progestagens desogestrel or gestodene. This analysis of data from 9 countries, involved 769 cases and 1979age matched hospital controls and, in one centre, 246 community controls matched on age and general practice. 137 cases and 203 controls were current users of levonorgestrel (odds ratio ŠOR with 95 percent confidence intervalĆ 3.5 Š2.6-4.7Ć), with non-users as the reference; 35 cases and 28 controls werecurrent users of desogestrel (9.1 Š4.9-17.0Ć), and 36 cases and 28 controls were current users of gestodene (9.1 Š4.9-16.7Ć). The ratios of theserisks, compared with levonorgestrel, were 2.6 (1.4-4.8) for both productsseparately. Risk estimates adjusted for body mass index (BMI) were 3.4, 7.3, and 10.2 for levonorgestrel, desogestrel, and gestodene, respectively, compared with non-users, and 2.2 and 3.0 for desogestrel and gestodene, respectively, compared with levonorgestrel. 48 (68 percent) cases and 48 (86 percent) controls exposed to desogestrel or gestodene were from theUK (Oxford region). In this centre risk estimates compared with non-users, adjusted for BMI, were 2.6, 5.3, and 5.7 for levonorgestrel, desogestrel, and gestodene, respectively. Current users of low oestrogen dose coed OCs containing desogestrel or gestodene appear to be at higher risk of VTE than users of combined OCs containing levonorgestrel. The possibility that these unexpected results on a secondary study objective are due to chance, bias, or residual confounding cannot be excluded entirely and the results need to be confirmed by independent studies.(trunc.)
    Vir: The Lancet. - ISSN 0140-6736 (Letn. 346, št. 8990, 1995, str. 1582-1588)
    Vrsta gradiva - članek, sestavni del
    Leto - 1995
    Jezik - angleški
    COBISS.SI-ID - 7743193

vir: The Lancet. - ISSN 0140-6736 (Letn. 346, št. 8990, 1995, str. 1582-1588)
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