Akademska digitalna zbirka SLovenije - logo
VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
PDF
  • Brain aggregoma with clonal B-cell perivascular proliferation detected by next-generation sequencing : a case report and review of the literature
    Matjašič, Alenka, biologija, 1986- ...
    Light-chain deposition disease (LCDD), a rare type of monoclonal immunoglobulin deposition disease, can be presented as systemic or localized, very rarely affecting central nervous system (CNS). Only ... 10 cases of CNS-LCDD have been described so far. We present an eleventh case of cerebral tumour-like LCDD, called aggregoma, and compare it with previously reported cases. A 49-year-old patient was admitted to the hospital due to a first generalized epileptic seizure. Magnetic resonance imaging (MRI) showed focal lesion in the right occipital lobe. Abundant parenchymal aggregates of pale eosinophilic material were observed, Congo red negative, Thioflavin T moderately positive, and l-light chain positive, but k negative in immunofluorescence with mild perivascular lymphoplasmacytic infiltrates in the intervening brain tissue. Clonality testing by next-generation sequencing showed the monoclonal nature of B-lymphocytes. Electron microscopy showed a finely granular ultrastructure of the aggregates without deposition in the vessel walls. A whole-body workup did not show any extra-cerebral immune dyscrasias.
    Vir: Folia Neuropathologica. - ISSN 1641-4640 (Vol. 59, no. 2, 2021, str. 205-211)
    Vrsta gradiva - članek, sestavni del ; neleposlovje za odrasle
    Leto - 2012
    Jezik - angleški
    COBISS.SI-ID - 92267267

    Povezava(-e):

    https://www.termedia.pl/Brain-aggregoma-with-clonal-B-cell-perivascular-proliferation-r-ndetected-by-next-generation-sequencing-A-case-report-r-nand-review-of-the-literature,20,44156,1,1.html
    DOI

vir: Folia Neuropathologica. - ISSN 1641-4640 (Vol. 59, no. 2, 2021, str. 205-211)
loading ...
loading ...
loading ...

Vnos na polico