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Relative bioavailability enhancement of simvastatin via dry emulsion systems : comparison of spray drying and fluid bed layering technologyPohlen, Mitja ...Comprehensive comparisons of similar lipid based drug delivery systems produced by different technologies are scarce. Spray drying and fluid bed layering technologies were compared with respect to ... the process and product characteristics of otherwise similar simvastatin loaded dry emulsion systems. Fluid bed layering provided higher process yield (83.3 % vs 71.5 %), encapsulation efficiency (80.0 % vs 68.4 %), relative one month product stability (93.8 % vs 85.5 %), larger and more circular particles (336 µm vs 56 µm) and lower median oil droplet size after product reconstitution in water (2.85 µm vs 4.27 µm), compared to spray drying. However, spray dried products exhibited higher drug content (22.2 mg/g vs 9.34 mg/g). An in-vivo pharmacokinetic study in rats was performed and a pharmacokinetic model was developed in order to compare the optimised simvastatin loaded dry emulsion systems, a simvastatin glyceride mimetic loaded in the dry emulsion and a simvastatin loaded SMEDDS with a reference physical mixture. Of the formulation tested, fluid bed layered pellets excelled and provided a 115 % relative increase in bioavailability. Among the two technologies, fluid bed layering provided dry emulsion products with higher relative bioavailability and better product characteristics for further processing into final dosage forms.Vir: European journal of pharmaceutics and biopharmaceutics. - ISSN 0939-6411 (Vol. 172, 2022, str. 228-239)Vrsta gradiva - članek, sestavni del ; neleposlovje za odrasleLeto - 2022Jezik - angleškiCOBISS.SI-ID - 93593859
Avtor
Pohlen, Mitja |
Zdovc, Jurij, farmacija |
Trontelj, Jurij |
Mravljak, Janez, 1978- |
Gosenca Matjaž, Mirjam |
Grabnar, Iztok |
Snoj, Tomaž |
Dreu, Rok
Teme
Farmacevtska tehnologija |
simvastatin |
suha emulzija |
sistemi za dajanje zdravil na osnovi lipidov |
plastenje s tekočo plastjo |
sušenje z razpršilom |
farmakokinetično modeliranje |
simvastatin |
dry emulsion |
lipid based drug delivery systems |
fluid bed layering |
spray drying |
pharmacokinetic modelling
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Avtor | Pohlen, Mitja ... |
Naslov | Relative bioavailability enhancement of simvastatin via dry emulsion systems : comparison of spray drying and fluid bed layering technology |
Datum objave | 2022-03-30 |
COBISS.SI-ID | 93593859 |
Verzija objave v repozitoriju | Založnikova različica |
Licenca objave v repozitoriju | Creative Commons Priznanje avtorstva 4.0 Mednarodna |
Embargo | Takojšnja javna objava |
Projekti, iz katerih je bila financirana objava
Naziv | Akronim | Številka projekta | Financer |
---|---|---|---|
Farmacevtska tehnologija: od dostavnih sistemov učinkovin do terapijskih izidov zdravil pri otrocih in starostnikih | P1-0189-2018 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Pohlen, Mitja | 50269 |
Zdovc, Jurij, farmacija | 51148 |
Trontelj, Jurij | 23420 |
Mravljak, Janez, 1978- | 23419 |
Gosenca Matjaž, Mirjam | 29887 |
Grabnar, Iztok | 16107 |
Snoj, Tomaž | 13441 |
Dreu, Rok | 21455 |
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