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  • Growth hormone (GH) treatment reverses early atherosclerotic changes in GH-deficient adults
    Pfeifer, Marija ...
    Hypopituitary patients have increased mortality from vascular disease, and in these patients, early markers of atherosclerosis (increased carotid artery intima-media tickness (IMT) and reduced ... distensibility) are more prevalent. AsGH replacement can reverse some risk factors of atherosclerosis, the presentstudy examined the effect of GH treatment on morphological and functional changes in the carotid and brachial arteries of GH-deficient (GHD) adults. Eleven GHD hypopituitary men (24-49 yr old) were treated with recombinant human HG (0.018 U/kg BW-day) for 18 months. IMT of the common carotid artery (CCA) and the carotid bifurcation (CB), and flow-mediated endothelium-dependent dilation (EDD) of the brachial artery were measured by Bmode ultrasound before and at 3, 6, 12, and 18 months of treatment, and values were compared with those in 12 age-matched control men. Serum concentrations of lipids, lipoprotein(a), insulin-like growth factor I (IGF-I), and IGF-I), IGF-binding protein-3 (IGFBP-3) were also measured. In GHD men before treatment the IMTs of the CCA (mean(SD), 0.67(0.05) mm) and CB (0.75(0.04) mm) were significantly greater (P < 0.001) than thos ein control men (0.52(0.07) and 0.65(0.07) mm, respectively). GH treatment normalized the IMT of the CCA by 6 months (0.53(0.04) mm) and that of the CB by 3 months (0.68(0.05) mm). The IMT of the carotid artery (CCA and CB) was negatively correlated with serum IGF-I (r=- 0.53; P < 0.0001). There was a significant improvement in flow-mediated EDD of the brachial artery at 3 months, which wassustained at 6 and 18 months of GH treatment (P < 0.05). GH treatment increased high density lipoprotein cholesterol at 3 and 6 months, but did not reduce total or low density lipoprotein cholesterol and was without effect on lipoprotein(a). (Abstract tuncated at 2000 characters)
    Vir: The Journal of clinical endocrinology & metabolism. - ISSN 0021-972X (Letn. 84, št. 2, 1999, str. 453-457)
    Vrsta gradiva - članek, sestavni del
    Leto - 1999
    Jezik - angleški
    COBISS.SI-ID - 9865689

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