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  • Chemical radioprotection (WR-2721) in patients with head and neck cancer = Kemični radioprotektor (WR-2721) pri bolnikih s karcinomom glave in vratu
    Wagner, Wolfgang ; Radmard, Afshin ; Boyomo, Armand-Belebeine
    Background and methods. Amifostine was given as daily intravenous application (200mg/m2) 10-15 minutes prior to radiotherapy in 36 patients with locally advanced head and neck tumors to spare normal ... tissues, such as the salivary glands and oral cavity, from irradiation. Postoperative radiotherapy was carried out to a complete dose of 60 Gy given in 30 days, with single doses of2 Gy. Side effects of radiotherapy were assessed using the WHO-criteria. Results. According to the WHO-score, mucositis occurred in 10 patients (grade 1) and 26 patients (grade 2). Dysphagia was recorded in 10 patients as grade 1and in 12 patients as grade 2. Xerostomia was established as grade 1 in 14 patients and as grade 2 in 16 patients. Skin reactions were grade 1 in 9 patients and grade 2 in 13 patient. Drug related toxicity was recorded in 12 patients: hypotension grade 1 and nausea grade 2 were observed in 3 patients, while vomiting grade1 and grade 2 were documented in 3 and 1 patient respectively. Conclusions. According to the data from the literature, we believe that the application of amifostine is feasible, and amifostine is an effective radioprotector decreasing both acute and late side effects in patients irradiated for head and neck tumors.
    Vir: Radiology and oncology. - ISSN 1318-2099 (Letn. 33, št. 2, 1999, str. 153-157)
    Vrsta gradiva - članek, sestavni del
    Leto - 1999
    Jezik - angleški
    COBISS.SI-ID - 9974745

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    Digitalna knjižnica Slovenije - dLib.si

vir: Radiology and oncology. - ISSN 1318-2099 (Letn. 33, št. 2, 1999, str. 153-157)
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