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Fakulteta za kmetijstvo in biosistemske vede, Maribor (FKMB)
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  • Improvement of lipid profile by probiotic/protective cultures : study in a non-carcinogenic small intestinal cell model
    Gorenjak, Mario ...
    Plasma lipid levels are important risk factors for the development of atherosclerosis and coronary heart disease. Previous findings have shown that probiotic bacteria exert positive on ... hypercholesterolemia by lowering serum cholesterol and improving lipid profile that, in turn, leads to a reduced risk of coronary heart disease and atherosclerosis. Most of these studies were carried out with tumoral cell lines that have a metabolism quite different from that of normal cells and many thus respond differently to various stimuli. Here,we demonstrate the beneficial effect of some probiotic on cholesterol levels and pathways in normal small intestinal foetal epithelial tissue cells. The results show that Lactobacillus plantarum strain PCS 26 efficeintly removes cholesterol from meia, exhibits bile salt hydrolise activity, and up-regulates several genes involved in cholesterol metabolism. This study sugests that Lactobacillus plantarum PCS 26 might act as a liver X receptor agonist and help to improve lipid profiles in hypercholesterolemic patients or even dislipidemias in complex diseases such as the metabolic syndrome
    Vir: The New microbiologica : journal of basic and clinical microbiological sciences. - ISSN 1121-7138 (Vol. 37, No. 1, 2014, str. 51-64)
    Vrsta gradiva - članek, sestavni del
    Leto - 2014
    Jezik - angleški
    COBISS.SI-ID - 3662124

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