Odziv človeškega gena za lanosterolno 14[alfa]-demetilazo na cAMP odvisno in od sterolov odvisno uravnavanje : magistrsko delo
Fink, Martina
Lanosterol 14alpha-demethylase (CYP51) is the most conserved member of the cytochrome P450 gene superfamily. Enzymes with CYP51 activity are found in alleucaryotic phyla and also in one bacteria ...(Mycobacterium tuberculosis). CYP51 is a part of a housekeeping process of cholesterol biosynthesis in animals. It removes 14alpha-methyl group from lanosterol producing FF-MAS. MAS(meiosis activating sterols) are intermediates in cholesterol biosynthetic pathway in somatic cells while in germ cells (ovary and testis) they accumulate. MAS sterols can in in vitro conditions reinitiate meiosis in mouseoocytes. CYP51 is ubiquitously expressed with the highest level in testis. In the promoter regulatory regions of mammalian (human, rat, mouse) CYP51 genes conserved regulatory DNA sequences - cAMP responsive elements (CRE1, CRE2, CRE3) and sterol regulatory elements (SRE1 and SRE2) were identified suggesting that both cAMPdependent and sterol-dependent types of regulation may control expression of CYP51. In human, rat and mouse different CYP51 transcripts have been identified. The longer are expressed in all tissues, while the shortest are expressed only in testis of sexullaly mature animals. Somatic transcripts and shorter testis specific transcripts have beenidentified in all studied mammals. Appearance of the shortest transcripts in mouse and human coincides with the appearance of CREMt protein, a well known inducer of numerous germ cell specific genes. Mobility shift experimentshave confirmed that all three cAMP reponsive elements (CRE1, CRE2, CRE3) present in human CYP51 promoter bind cAMP responsive transcription factors. Human CYPS1 CRE1 and CRE2 interact with transcription factors presentin somatic cell nuclear extracts as well as in male germ cells. Recombinant human sterol regulatory element binding proteins (SREBP) can in invitro conditions bind to SRE1 element. (Abstract truncated at 2000 characters.)
Vrsta gradiva - magistrsko delo
Založništvo in izdelava - Ljubljana : [M. Fink], 2000
Bibliografsko gradivo je bilo uspešno dodano na polico.
Dodajanje bibliografskega gradiva na polico ni uspelo.
Gradivo je že na polici.
Trajna povezava
URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto
Faktor vpliva
Izdaja
Kategorija
Razvrstitev
JCR
SNIP
JCR
SNIP
JCR
SNIP
JCR
SNIP
Izberite knjižnično izkaznico:
Baze podatkov,
v katerih je revija indeksirana
Ime baze podatkov
Področje
Leto
Povezave do osebnih bibliografij avtorjev
Povezave do podatkov o raziskovalcih v sistemu SICRIS
Storitev za pridobivanje naslova trenutno ni dostopna, prosimo, poskusite še enkrat.
S klikom na gumb "V redu" boste potrdili zgoraj izbrano prevzemno mesto in dokončali postopek rezervacije.
S klikom na gumb "V redu" boste potrdili zgoraj izbrano prevzemno mesto in naslov za dostavo ter dokončali postopek rezervacije.
S klikom na gumb "V redu" boste potrdili zgoraj izbrani naslov za dostavo in dokončali postopek rezervacije.
Obvestilo
Trenutno je storitev za avtomatsko prijavo in rezervacijo nedostopna. Gradivo lahko rezervirate sami na portalu Biblos ali ponovno poskusite tukaj kasneje.
Citiranje
Funkcionalnost trenutno ni na voljo. Prosimo, poskusite kasneje.
