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  • Sproženje in zdravljenje anafilaktičnega šoka = Triggering and treatment of anaphylactic shock
    Grosek, Štefan
    Anaphylactic shock is a clinical syndrome with a typical clinical picture and course, due to the release and action of histamine and other preformed and newly synthetisized mediators of anaphylaxis, ... targeting endothelial cell, smooth muscles of bronchi, gut and vessels. After sensitization of the organism, or even without it, if direct injection of allergen into circulationoccurs, allergen binds IgE on mastocytes and degranulation and release of histamine ensues together with the generation of new mediators. Some drugs, peptides, venoms and other agents are capable of direct activationof mastocytes bypassing the ligation to IgE. Treatment of anaphylactic shock enconters injection of epinephrine subcutaneously or intramuscularly or even intravenously in most sever causes. In bronchospasm with wheezing an aminophyllin is needed, and after that the patients receives H1- and H2-receptor antagonists and corticosteroids. Aggressive antishock fluid therapy with crystalloid is needed often together with catecholamines incontinuous infusion when cardiocirculatory failure is impeding. Treatment should be started immediately and continued in an intensive care unit at leastfor 48 hours to prevent late reactivation of anaphylactic shock and othercomplications.
    Vir: Medicinski razgledi. Supplement. - ISSN 0353-3484 (Letn. 38, supl. 7, nov. 1999, str. 121-130)
    Vrsta gradiva - članek, sestavni del
    Leto - 1999
    Jezik - slovenski
    COBISS.SI-ID - 10936025

vir: Medicinski razgledi. Supplement. - ISSN 0353-3484 (Letn. 38, supl. 7, nov. 1999, str. 121-130)

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