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  • Vpliv zdravil na tveganje zbolevanja za jetrno cirozo = Impact of drugs on the morbidity risk of liver cirrhosis
    Grobovšek-Opara, Sonja, 1946-
    Starting-points. Numerous chronic liver diseases, and among them also liver cirrhosis, can be attributed to drugs. Presented results of the research on the impact of alcohol, nutrition and drugs on ... the morbidity risk owing to liver cirrhosis show the degree of connectedness of drug consumption with teh onset of liver cirrhosis. Methods. Research was a study of cases with controlswhich 182 included newly diagnosed patients with liver cirrhosis on departments for internal diseases of Slovenian hospitals during the period from January to July 1995. Liver cirrhosis was diagnosed on the base of clinical picture, corresponding laboratory results and ultrasound examination.Control persons were inhabitants of Slovenia, matched with patients by sex, age and permanent residence. Data were collected by interviewin person. In variate and multivariate data analysis, the method of conditional logistic regression was used. Drugs were divided into four groups.. The first group the known hepatotoxic drugs and the other three groups included sex hormons, vitamins and other drugs. Results. A greater consumption of hepatotoxic drugs and vitamins was found in patients, while there were no significant differences between patients and control persons as far as consuming sex hormons and other drugs is concerned. The number of persons consuming vitamin vitamin preparation was small and was not reliably connected with the onset of liver cirrhosis in the multivariate analysis. The following hepatotoxic drugs: methyldopa, papaverine, propylthiouracil, sulfonamides, phenofibrate, paracetamol, acetylsaliclyc acid, isoniazid, tolbutamide, haloperidol, retinol and amiodarone hydrochloride were consumed in greater number by patients than by control persons. (Abstract truncated at 2000 characters).
    Vir: Zdravstveno varstvo : Slovenian journal of public health. - ISSN 0351-0026 (Letn. 38, št. 11/12, 1999, str. 393-398)
    Vrsta gradiva - članek, sestavni del
    Leto - 1999
    Jezik - slovenski
    COBISS.SI-ID - 10963929

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