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  • Granulocitni antigeni in njihov klinični pomen = Granulocyte antigens and their role in clinical medicine
    Maček, Marjeta, 1966-
    The neutrophil-specific antigens HNA-1 a, HNA-1b and HNA-1 c are the clinically most important antigens on the neutrophil membrane. They are identified as polymorphic forms of the FcyRIIIb receptor, ... which is determined biochemically and on the molecular level. Antibodies against granulocyte antigens can be produced following the transfusion of granulocytes, in pregnancy and following bone marrow transplantation. They cause alloimmune neonatal neutropenia, immune neutropenia after bone marrow transplantation, refractoriness to granulocyte transfusion and transfusion reactions such as TRALI (Transfusion-related acute lung injury) syndrome and febrile nonhemolytic transfusion reaction. If own granulocyte antigens are the target of the immune response, autoimmune neutropenia and drug-induced neutropenia occur. For the diagnosis of these clinical conditions the determination of granulocyte antibodies is essential. Granulocyte antibodies are mostly determined by the immunofluorescence test, agglutination test and MAIGA (monoclonal antibody-specific immobilisation of granulocyte antigens) assay. The latter allows determination of the granulocyte antibody specificity. Anti-gens HNA-1a, HNA-1b and HNA-1c can be genotyped by polymerase chain reaction with sequence-specific primers.
    Vir: Medicinski razgledi. Supplement. - ISSN 0353-3484 (Letn. 39, supl. 5, okt. 2000, str. 227-233)
    Vrsta gradiva - članek, sestavni del
    Leto - 2000
    Jezik - slovenski
    COBISS.SI-ID - 12332505

vir: Medicinski razgledi. Supplement. - ISSN 0353-3484 (Letn. 39, supl. 5, okt. 2000, str. 227-233)

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