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  • Analysis of 405 episodes of pneumococcal bacteremia in adults over a 15-year period = Analiza 405 primerov pnevmokokne bakteriemije pri odraslih v obdobju 15 let
    Trampuž, Andrej
    Background. HIV-infection and increasing drug resistance may influence the prognosis of pneumococcal bacteremia. We performed an observational cohort study to analyze the epidemiology, risk factors, ... and outcome for pneumococcal bacteremia during a 15 year period. Methods. Charts were reviewed from hospitalized adults at the University Hospital Basel, Switzerland, whose bloodculture yielded Streptococcus pneumoniae in the period from January 1986 through December 2000. Results. 405 episodes of pneumococcal bacteremia in 394patients were identified. The mean annual incidence was 1.78 episodes per 1, 000 hospital admissions. Most common risk factors were cigarette smoking, chronic lung disease, malignancy, and alcohol misuse. HIV-infection was known in 46 episodes (11%). During the study period, the nonsusceptibility of pneumococci against penicillin increased from 0% to 17%. The overall mortalitywas 25%. The case-fatality rate decreased from 32% to 17% during the second half of the study period (P <0.001). Independent risk factors for fataloutcome were coronary heart disease, neutropenia, and increasing age, whereas prior respiratory infection and the occurrence of bacteremia in the second half of the study period were independent predictors of survival. Mortality in HIV-infected patients was lower than in HIV-noninfected subjects (9% versus 27%, P = 0.007). Conclusions. Despite increased numbers of penicillin-nonsusceptible strains, mortality of pneumococcal pneumonia significantly decreased in the second half of study period.
    Vir: Zdravniški vestnik : glasilo Slovenskega zdravniškega društva = Slovenian medical journal = journal of Slovenian Medical Association. - ISSN 1318-0347 (Letn. 71, št. 10, okt. 2002, str. 607-614)
    Vrsta gradiva - članek, sestavni del
    Leto - 2002
    Jezik - angleški
    COBISS.SI-ID - 15490521

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