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  • Genetic polymorphism of cytochromes P450 2C9 and 2C19 in Slovenian population = Genetski polimorfizem citokromov P450 2C9 in 2C19 v slovenski populaciji
    Herman, Darja ; Dolžan, Vita ; Breskvar, Katja
    Background. Cytochrome P4502C9 (CYP2C9) and 2CT 9 (CYP2C19) participate in metabolism of many clinically important drugs. Genetic polymorphisms of the CYP2C9 and CYP2C19 genes are described which may ... affect drug treatment The aimof this study was to determine the frequencies of polymorphic CYP2C9 and CYP2C19 alleles in Slovenian population in order to estimate the proportion ofthe population that might experience adverse drug reaction. Methods. The polymorphism of CYP2C9 and.CYP2C19 was analysed by a genotyping technique, based on polymerase chain reaction (PCR) followed by restriction enzyme analysis. DNA samples from 129 unrelated healthy subjects were obtained from the Blood Transfusion Centre of Slovenia and University Children š Hospital inLjub jana. Results. In the analysed group of samples one-third of individuals carried at least one of the defective CYP2C9 alleles while among them 3.2% of individuals had both alleles affected. The frequencies of CYP2C9*2 and CYP2C9*3 were 0.122 and 0.063, respectively. Almost one-third of Slovenian individuals analysed carried at least one of the CYP2C19 polymorphicallele. The frequencies of CYP2C19*2 and CYP2C19*3 were 0.159 and 0.004, respectively. Conclusions. The results of our study indicate that approximately one-third of the patients from Slovenian population may require either adjustments of dose or increased monitoring when initiating treatment with CYP2C9 and CYP2C19 substrates having a narrow therapeutic index. High risk of adverse drug reaction may be expected in 1-3% of eventual patients.
    Vir: Zdravniški vestnik : glasilo Slovenskega zdravniškega društva = Slovenian medical journal = journal of Slovenian Medical Association. - ISSN 1318-0347 (Letn. 72, št. 6, jun. 2003, str. 347-351)
    Vrsta gradiva - članek, sestavni del
    Leto - 2003
    Jezik - angleški
    COBISS.SI-ID - 16588249

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    Digitalna knjižnica Slovenije - dLib.si

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