Protitumorsko delovanje lentogenega seva LaSota virusa bolezni Newcastle na mišji melanom B16F10 = Antitumorous effects of a lentogenic Newcastle disease virus strain LaSota on mouse B16F10 melanoma
Ivanković, Siniša ; Jurin, Mislav
Many viruses including Newcastle disease virus (NDV), an avian pathogen, have been shown to have an inhibitory effect on some tumors. Lentogenic strain NDV LaSota is apathogenic for its natural host ...(poultry) and it is used as a conventional vaccine strain against Newcastle disease in birds. The aim of this study was to investigate the influence of NDV strain LaSota on the B16F10tumor and L929 normal cells in culture as well as its effects on experimental melanoma growth in mice. In addition to the possible immunomodulation, the effect of LaSota virus on tumor-bearing mice was also investigated. In vitro results showed that LaSota virus had cytotoxic effect on mouse melanoma B16F10 cells and that the effect was dose dependent. In contrast to tumor cells, cytotoxic effects in normal L929 fibroblasts exposed to the virus were negligible. Results obtained in vivo showed that both intraperitoneal and intratumoral application of three doses of NDV LaSota can significantly inhibit B16F10 melanoma growth in mice, although a systemic intraperitoneal application was more effective than an intratumoral application. Proliferative response of splenocytes and lymph node lymphocytes from virus-treated mice to concanavalin A (ConA) exhibited some inhibitory effect 24 hours after virus application, while on day 6 after virus application, a stimulatory effect on ConA-induced lymph node lymphocyte proliferation was observed.
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