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  • Angiotensin-converting enzyme gene polymorphism and acute coronary syndrome = Polimorfizmi gena za encim angiotenzinsko konvertazo pri bolnikih z akutnim koronarnim sindromom
    Černe, Andreja, 1967- ; Kranjec, Igor, 1946- ; Peterlin, Borut, 1963-
    Objective. Angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism was recently associated with an increased risk for coronary artery disease (CAD), however the precise mechanism of ... this association remains unknown. Higher level of circulating ACE activity, described in DD genotype carriers may predispose to vascular wall thickening and increased vascular tone. The aims of our study were to assess ACE I/D polymorphism in patients with new onset CAD and to investigate whether ACS I/D polymorphism modulates structural and functional arterial changes in these patients. Methods. One hundred consecutive patients with acute coronary syndrome (ACS) as a first clinical manifestation of obstructive CAD and 80 healthy subjects underwent ACE I/D genotyping by polymerase chain reaction. The carotid intima-media thickness (IMT) and brachial endothelium-dependent (flow-mediated) as well as endothelium-independent (glyceryltrinitrate-induced) dilation were measured by the echo Doppler technique. Results. The ACE DD genotype occurred more frequently in ACS patients than in controls (37% vs. 21%; p<0.05). By multivariate regression analysis adjusting for traditional CAD predictors, the ACE DD genotype conferred a 2.4-fold increased risk for ACS (95% CI 1.1-6.6; p<0.05). In ACS patients, the DD genotype was associated with a significantly increased carotid IMT (DD vs. II; 0.94+-0.20 mm vs. 0.79+-0.20 mm; p<0.05) and impaired brachial endothelium-dependent dilation (DD vs. II; 5.9+-4.2% vs. 8.7+-2.9%, p<0.05). Conclusion. ACE I/D polymorphism emerged as an independent risk factor for ACS in our study population. A positive association between the ACEDD genotype and early structural and functional arterial changes was detected, suggesting a possible pathogenetic link between the ACE polymorphismand the underlying disease.
    Vir: Slovenska kardiologija : znanstveno strokovna revija za področje srčno-žilne medicine. - ISSN 1581-8543 (Vol. 2, no. 2, 2005, str. 100-104)
    Vrsta gradiva - članek, sestavni del
    Leto - 2005
    Jezik - angleški
    COBISS.SI-ID - 20127193

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