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  • Characterization of Physical Forms of Donepezil Hydrochloride
    Vrbinc, Miha, 1976- ...
    Different crystal forms and amorphous form of donepezil hydrochloride were prepared and characterized, using various analytical techniques. Hydrate form I is stable only at lower relative humidity ... (RH), while at higher RH it sorbesadditional water. Forms II, III and V were identified as polymorphs, whereas form III is thermodynamically stable. Form V was prepared by heating of hydrate IV at high temperature (about 150 °C). Three different forms of hydrate IV were obtained and characterized. Differential scanning calorimetry and X-ray powder diffraction are the most promising analytical methods for differentiation between crystal forms, both polymorphs and hydrates. Methods could be also used in determination of physical form of a drug, incorporated into solid dosage form. Thermal methods explain the most significant difference in dehydration of different forms IVČ transformation to pure polymorphic forms or mixture thereof. On heating of hydrates I and IV-1, two novel crystal forms were prepared and characterized, namely crystal forms VII and VIII.
    Vir: Acta chimica slovenica. - ISSN 1318-0207 (Vol. 54, no. 2, 2007, str. 254-267)
    Vrsta gradiva - članek, sestavni del
    Leto - 2007
    Jezik - angleški
    COBISS.SI-ID - 2149233

    Povezava(-e):

    Digitalna knjižnica Slovenije - dLib.si

vir: Acta chimica slovenica. - ISSN 1318-0207 (Vol. 54, no. 2, 2007, str. 254-267)

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