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  • Analytical investigation of properties of the iso-NTCP envelope
    Stavrev, Pavel ...
    Background. A property of the integral dose-volume histogram (DVH) space is analytically investigated in this work. A curve called an alpha-iso-NTCP (normal tissue complication probability) envelope ... is constructed by connectingpoints belonging to step-like integral DVHs, each corresponding to homogeneous partial organ irradiation of a relative volume vk to dose Dk such that the resulting NTCP has, in all cases, a particular value alpha. The two subspaces into which the envelope divides the DVH space are analytically explored in terms of the equivalent uniform doses (EUDs) corresponding to the different DVHs. It is theoretically proven that any DVH, other than the step-like DVH, passing through a point (Dk1 vk) from the alpha-iso-NTCP envelope, will result in an NTCP > alpha. Conclusions. Thus, it is proven thatany DVH that at least partially lies above the envelope results in an NTCP> alpha. For some of the DVHs lying under the envelope, e.g. those that are tangential to the envelope, it is also true that the resulting NTCP > alpha. However, it was numerically demonstrated elsewhere that there east DVHslying entirely in the lower subspace that result in an NTCP < alpha. Therefore, one can conclude that since there is a chance that a DVH lying under the alpha-iso-NTCP envelope will result in NTCP < alpha, it would be preferable in the treatment optimization process to seek solutions for DVHs lying entirely under an iso-NTCP envelope and avoid solutions that have DVHs above an iso-NTCP envelope.
    Vir: Radiology and oncology. - ISSN 1318-2099 (Vol. 41, no. 1, mar. 2007, str. 41-47)
    Vrsta gradiva - članek, sestavni del
    Leto - 2007
    Jezik - angleški
    COBISS.SI-ID - 22731737

vir: Radiology and oncology. - ISSN 1318-2099 (Vol. 41, no. 1, mar. 2007, str. 41-47)

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