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  • Immunocytochemical properties of filaments in the dystrophic neurites of Alzheimer's disease = Imunocitokemične lastnosti filamentov v distrofičnih nevritih pri Alzheimerjevi bolezni
    Praprotnik, Darja, 1964-, zdravnica
    Background. Senile plaques of Alzheimer's disease are comprised of fibrillary deposits of amyloid beta in the centre, surounded by degenerating or dystrophic neurites. The dystrophic neurites contain ... abnormal paired helical filaments, straight filaments and various vesicles. The relationship between the dystrophic neurites and the extracellular amyloid beta deposits is not clarified. It has been shown, that the abnormal filaments in the dystrophic neurites contain protein tau, ubiquitin and neurofilaments. The dystrophic neurites also contain epitopes of beta-precursor protein and-or amyloid beta and the components of extracellular matrix. In this study we tried to find out, if beta-precursor protein-amyloid beta epitopes are present on tau-positive filaments of dystrophic neurites. Material and methods. In the study autopsy tissue from brain cortex of four patients fulfilling the internationally confirmed criteria for the diagnosis of Alzheimer's disease were included. Light and electron double immunostaining methods were performed. We used antisera specific for protein tau, ubiquitin, beta-precursor protein-amyloid beta, synaptophysin and glial fibrillary acidic protein GFAP. Results. The dystrophic neurites often contained protein tau, ubiquitin, synaptophysin and beta-precursor protein-amyloid beta epitopes, but not always simultaneously. Electron microscopic double immunogold staining methods showed consistent presence of protein tau and ubiquitin on paired helical filaments and straight filaments. These filaments often showed presence of beta-precursor protein-amyloid beta epitopes, which are also present on granular senile plaques outside the dystrophic neurites contained only beta-precursor protein-amyloid beta epitopes. GFAP was not present inside the plaques. Conclusion.(trunc.)
    Vir: Zdravniški vestnik : glasilo Slovenskega zdravniškega društva = Slovenian medical journal = journal of Slovenian Medical Association. - ISSN 1318-0347 (Letn. 65, št. 2, feb. 1996, str. 61-65)
    Vrsta gradiva - članek, sestavni del
    Leto - 1996
    Jezik - angleški
    COBISS.SI-ID - 4081369

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