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  • Stabilna in nestabilna aterosklerotična leha = Stable and unstable atherosclerotic plaque
    Blinc, Aleš
    Atherosclerosis progresses asymptomatically until superimposed arterial thrombosis is triggered by disruption of the fibrous cap of an advanced atheroma. Most fissures of atherosclerotic plaques ... remain asymptomatic, although the mural thrombus contributes to plaque growth and luminal narrowing. Disruption of an atheroma in coronary arteries that gives rise to nearly- occlusive or occlusive thrombosis results in unstable angina, myocardial infarction or sudden cardiac death. The risk of plaque disruption is much more dependent on plaque composition than on the degree of luminal narrowing. Unstable atherosclerotic plaques have a thin fibrous cap and an abundant lipid-rich core, which is highly thrombogenic due to its tissue factor content. Disruption of an atherosclerotic plaque is triggered by mechanical factors, but the susceptibility for rupture is determined by ongoing inflammation and repair within the atheroma. Macrophages secrete and activate matrix metalloproteinases that weaken the mechanical stability of thefibrous cap. Lowering the serum concentration of low density lipoprotein cholesterol has a beneficial effect on plaque stability.
    Vir: Medicinski razgledi. Supplement. - ISSN 0353-3484 (Letn. 37, supl. 3, apr. 1998, str. 85-90)
    Vrsta gradiva - članek, sestavni del
    Leto - 1998
    Jezik - slovenski
    COBISS.SI-ID - 7887577

vir: Medicinski razgledi. Supplement. - ISSN 0353-3484 (Letn. 37, supl. 3, apr. 1998, str. 85-90)

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