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Onkološki inštitut Ljubljana (OILJ)
  • Single-fraction versus 5-fraction radiation therapy for metastatic epidural spinal cord compression in patients with limited survival prognoses : results of a matched-pair analysis
    Rades, Dirk ...
    This study compared single-fraction to multi-fraction short-course radiation therapy (RT) for symptomatic metastatic epidural spinal cord compression (MESCC) in patients with limited survival ... prognosis. METHODS AND MATERIALS. A total of 121 patients who received 8 Gy x 1 fraction were matched (1:1) to 121 patients treated with 4 Gy x 5 fractions for 10 factors including age, sex, performance status, primary tumor type, number of involved vertebrae, other bone metastases, visceral metastases, interval between tumor diagnosis and MESCC, pre-RT ambulatory status, and time developing motor deficits prior to RT. Endpoints included in-field repeated RT (reRT) for MESCC, overall survival (OS), and impact of RT on motor function. Univariate analyses were performed with the Kaplan-Meier method and log-rank test for in-field reRT for MESCC and OS and with the ordered-logit model for effect of RT on motor function. RESULTS: Doses of 8 Gy x 1 fraction and 4 Gy x 5 fractions were not significantly different with respect to the need for in-field reRT for MESCC (P=.11) at 6 months (18% vs 9%, respectively) and 12 months (30% vs 22%, respectively). The RT regimen also had no significant impact on OS (P=.65) and post-RT motor function (P=.21). OS rates at 6 and 12 months were 24% and 9%, respectively, after 8 Gy % 1 fraction versus 25% and 13%, respectively, after 4 Gy % 5 fractions. Improvement of motor function was observed in 17% of patients after 8 Gy % 1 fraction and 23% after 4 Gy % 5 fractions, respectively.
    Vir: International journal of radiation oncology, biology, physics. - ISSN 0360-3016 (Vol.93, no. 2, 2015, str. 368-372)
    Vrsta gradiva - članek, sestavni del
    Leto - 2015
    Jezik - angleški
    COBISS.SI-ID - 2306939
    DOI

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