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Single-fraction versus 5-fraction radiation therapy for metastatic epidural spinal cord compression in patients with limited survival prognoses : results of a matched-pair analysisRades, Dirk ...This study compared single-fraction to multi-fraction short-course radiation therapy (RT) for symptomatic metastatic epidural spinal cord compression (MESCC) in patients with limited survival ... prognosis. METHODS AND MATERIALS. A total of 121 patients who received 8 Gy x 1 fraction were matched (1:1) to 121 patients treated with 4 Gy x 5 fractions for 10 factors including age, sex, performance status, primary tumor type, number of involved vertebrae, other bone metastases, visceral metastases, interval between tumor diagnosis and MESCC, pre-RT ambulatory status, and time developing motor deficits prior to RT. Endpoints included in-field repeated RT (reRT) for MESCC, overall survival (OS), and impact of RT on motor function. Univariate analyses were performed with the Kaplan-Meier method and log-rank test for in-field reRT for MESCC and OS and with the ordered-logit model for effect of RT on motor function. RESULTS: Doses of 8 Gy x 1 fraction and 4 Gy x 5 fractions were not significantly different with respect to the need for in-field reRT for MESCC (P=.11) at 6 months (18% vs 9%, respectively) and 12 months (30% vs 22%, respectively). The RT regimen also had no significant impact on OS (P=.65) and post-RT motor function (P=.21). OS rates at 6 and 12 months were 24% and 9%, respectively, after 8 Gy % 1 fraction versus 25% and 13%, respectively, after 4 Gy % 5 fractions. Improvement of motor function was observed in 17% of patients after 8 Gy % 1 fraction and 23% after 4 Gy % 5 fractions, respectively.Vir: International journal of radiation oncology, biology, physics. - ISSN 0360-3016 (Vol.93, no. 2, 2015, str. 368-372)Vrsta gradiva - članek, sestavni delLeto - 2015Jezik - angleškiCOBISS.SI-ID - 2306939
Avtor
Rades, Dirk |
Huttenlocher, Stefan |
Šegedin, Barbara |
Perpar, Ana |
Conde-Moreno, Antonio J. |
Garcia, Raquel, zdravnica |
Veninga, Theo |
Stalpers, Lukas J. A. |
Cacicedo, Jon |
Rudat, Volker |
Schild, Steven E.
Teme
radioterapija |
starejši pacienti |
doziranje |
preživetje |
radiotherapy |
elderly patients |
dosage |
survival
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vir: International journal of radiation oncology, biology, physics. - ISSN 0360-3016 (Vol.93, no. 2, 2015, str. 368-372)
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Rades, Dirk | ![]() |
Huttenlocher, Stefan | ![]() |
Šegedin, Barbara | 27754 |
Perpar, Ana | ![]() |
Conde-Moreno, Antonio J. | ![]() |
Garcia, Raquel, zdravnica | ![]() |
Veninga, Theo | ![]() |
Stalpers, Lukas J. A. | ![]() |
Cacicedo, Jon | ![]() |
Rudat, Volker | ![]() |
Schild, Steven E. | ![]() |
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